Frederick Zeiler is a Canadian neurosurgeon who was hired as a clinician-scientist at the University of Manitoba in 2019. He completed his BSc at the University of Manitoba, focused on applied mathematics and physical chemistry, holding National Sciences and Engineering Research Council (NSERC) summer research awards during this time. He went on to complete his medical school at the University of Manitoba, followed by his neurosurgery residency at the same institution, receiving certification in neurosurgery from the Royal College of Surgeons of Canada. Dr. Zeiler has also completed dedicated fellowship training in both: neurocritical care at the Montreal Neurological Institute, and the Royal College of Physicians and Surgeons of Canada (RCPSC) clinician investigator program at the University of Manitoba. Finally, he completed his PhD training at the University of Cambridge, with his studies focused on advanced multi-modal monitoring of cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI), under the supervision of world experts in TBI research: Prof David Menon and Prof Marek Czosnyka. During his time in Cambridge, he was recognized as both a Royal College of Surgeons of Canada Travelling Fellow in Surgery and University of Cambridge International Trust Scholar for the entirety of his studies. Dr. Zeiler is the author of over 150 peer-reviewed manuscripts, abstracts and text book chapter publications, and recipient of numerous awards for academic accomplishments. Currently, Dr. Zeiler is an Assistant Professor and Director of Neurosurgery Research within the Section of Neurosurgery, while recently being awarded the Rudy Falk Clinician-Scientist Professorship at the University of Manitoba, and holding guest researcher appointments at the University of Cambridge and Karolinska Institute.
His clinical practice focuses on the management of cranial neurotrauma, with his newly developing research program in Winnipeg focused on the application of multi-modal invasive/non-invasive cranial physiologic monitoring for the continuous assessment of cerebral autoregulation, compensatory reserve, autonomics and signal entropy. This program will integrate complex high-frequency signal processing, with neuroimaging, serum/CSF/microdialysis protein and genetic biomarkers. The goal is to uncover the molecular mechanisms involved in impaired cerebrovascular reactivity in TBI, leading to the development of potential therapeutic targets directed at prevention and treatment of vascular dysfunction in TBI. This program maintains strong ongoing collaborative ties with many international centers including: University of Cambridge, Karolinska Institute, University of Helsinki and Maastricht University.
1. Zeiler FA, Ercole A, Cabeleira M, Zoerle T, Stocchetti N, Menon DK, Smielewski P, Czosnyka M; CENTER-TBI High Resolution Sub-Study Participants and Investigators. Univariate Comparison of Performance of Different Cerebrovascular Reactivity Indices for Outcome Association in Adult TBI: A CENTER-TBI Study. Acta Neurochir (Wien). 2019, In Press.
2. Zeiler FA, Thelin EP, Donnelly J, Stevens A, Smielewski P, Czosnyka M, Hutchinson PJ, Menon DK. Genetic drivers of cerebral blood flow dysfunction in traumatic brain injury: a speculative synthesis. Nat Rev Neurol. Accepted, August 21st 2018.
3. Zeiler FA, Ercole A, Cabeleira M, Carbonara M, Stocchetti N, Menon DK, Smielewski P, Czosnyka M; CENTER-TBI Participants and Investigators. Comparison of Performance of Different Optimal Cerebral Perfusion Pressure Parameters for Outcome Prediction in Adult TBI: A CENTER-TBI Study. J Neurotrauma. 2018 Nov 1. doi: 10.1089/neu.2018.6182. [Epub ahead of print]
4. Zeiler FA, Smielewski P, Stevens A, Czosnyka M, Menon DK, Ercole A. Non-Invasive Pressure Reactivity Index Using Doppler Systolic Flow Parameters: A Pilot Analysis. J Neurotrauma. 2018 Sep 27. doi: 10.1089/neu.2018.5987. [Epub ahead of print
5. Zeiler FA, Donnelly J, Smielewski P, Menon DK, Hutchinson PJA, Czosnyka M. Critical Thresholds of ICP Derived Continuous Cerebrovascular Reactivity Indices for outcome prediction in Non-Craniectomized TBI Patients: PRx, PAx and RAC. J Neurotrauma. 2018; 35(10):1107-1115. doi: 10.1089/neu.2017.5472.
University of Manitoba
Rudy-Falk Clinician-Scientist Professor
Director of Neurosurgery Research
Assistant Professor, Department of Surgery
International Academic Affiliations
Guest Researcher, Division of Anaesthesisa
University of Cambridge
Neurosurgeon-Scientist, Health Sciences Center, Winnipeg, MB
Human Anatomy and Cell Science