Arthur Quanbury, MASc, PEng
Assistant Professor
School of Medical Rehabilitation, Occupational Therapy
quanbry@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Lifetime career research interest and activity in the areas of biomechanics and motion analysis including EMG analysis. More recent areas include augmentative and alternative communication, ergonomics, particularly with a biomechanical emphasis and assistive technology, both the development of AT products and the study of its effectiveness and impact on the lives of individuals with disabilities. Currently involved in the evaluation of a light touch keyboard for people with repetitive strain injuries and an ergonomic study of ultrasound sonographers in Manitoba.
Mojgan Rastegar, PhD, DEA (Diplome d'Etudes Approfondies), MSc, BSc
Assistant Professor
Regenerative Medicine Program, Biochemistry & Medical Genetics
rastegar@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
My research program is aimed towards understanding the Epigenetic Control of Adult and Embryonic Stem Cell Neurogenesis and their Application in Regenerative Medicine.
We are interested in the role of HOX proteins, their cofactors and targets in Neural Stem Cell/Brain Cancer Stem Cell Fate Decisions. We further study the role of Chromatin Remodeling Factors and Epigenetic Modulators in Stem Cell Neuronal Differentiation.
Our focus is also on the Gene Therapy of Rett Syndrome (RTT). RTT is the main cause of mental retardation in females and is caused by mutations in the MeCP2 gene. We are applying gene transduction approaches in RTT mouse model and performing genomics and proteomics, to identify MeCP2 neuronal targets for alternative therapy strategies.
Jeffrey Reiss, MD, MSc, FRCPC, FAPA
Associate Professor
Psychiatry
jpreiss@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
I am involved in psychiatric neuroimaging research, in particular using fMRI in the area of schizophrenia. Along with other members of our group, we are studying Anxiety Disorders as well. We are interested in cognition and emotional processing in these clinical groups.
Julia Rempel, PhD, BSc
Assistant Professor
Internal Medicine, Immunology
jdrempel@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Dr. Julia Rempel's research program is investigating aboriginal health with respect to liver diseases. Her research team is the first to investigate how Aboriginal immunity might interact with hepatitis C virus, pairing genetic and cell behavior analyses. Their current findings were provided to the Aboriginal community partners in a research video produced by Dr. Rempel. Oji-Cree and English versions of the video can be viewed at http://home.cc.umanitoba.ca/~jdrempel.
In addition, her laboratory is studying how proteins from hepatitic viruses can alter and evade immunity using cell culture systems in collaboration with researchers from the NML. Understanding the interaction of viral proteins with their immune counterparts may provide future therapeutic targets for addressing complications associated with infection or resolution of the infection.
Gayle Restall, MSc, BMR (OT)
Assistant Professor
School of Medical Rehabilitation, Occupational Therapy
g_restall@umanitoba.ca
Open for Collaboration
Research focuses on primary health care and consumer participation in health system planning.
Recent and current projects include:
- Participation of users of mental health services in planning and evaluating services
- Early identification of preschool children with developmental risk factors
- Implementing client-centred service delivery models
- Integration of occupational therapy and physiotherapy in primary health care service delivery models
Jacquie Ripat, BMR (OT, MSc (Rehabilitation); OT Reg (MB); OT(C)
Assistant Professor
Occupational Therapy
ripatj@cc.umanitoba.ca
Accepting Graduate Students
Open to Collaboration
My primary area of research expertise is in the area of assistive technology. Using a lifespan approach to research in the area of assistive technology, I seek to discover ways in which the technological environment can be used or adapted to enable persons with disabilities to meet their desired goals and fulfill their roles. To date, my work is comprised of three key areas:
1. Development and evaluation of the impact of new, improved or current technologies and service delivery models.
2. Accessibility of public technologies and physical environments.
3. Understanding the meaning and experience of assistive technology for young adults with disabilities and their families.
Cheryl Rockman-Greenberg, MD, CM, FRCPC(Peds), FRCPC(MedGen),
FAAP, FCCMG
Professor
Pediatrics & Child Health, Biochemistry & Medical Genetics
cgreenberg@ms.umanitoba.ca; cgreenberg@hsc.mb.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
Most of my research activities have focused on the identification of the molecular basis for specific/inborn errors of metabolism and the subsequent development of diagnostic or screening programs relevant to patient care and arising from research findings. My current research focuses on the fatty acid oxidation disorder known at CPT-1 deficiency which is over-represented in the Hutterite community in Manitoba and the Inuit from Kivalliq, Nunavut. I have also been able to facilitate large family studies for gene mapping and positional cloning ventures in the field of limb girdle muscular dystrophies. Bowen-Conradi syndrome, sulphite oxidase deficiency and COFS syndrome - all diseases highly relevant to Manitoba populations. I have been an active advocate for vitamin D supplementation in Manitoba populations at high-risk for Vitamin D deficiency and I am involved in a Bone Health study in Aboriginal communities. Community participation in research endeavors and their application to patient care has always been a major priority.
Leslie Roos, PhD
Professor
Community Health Sciences
Leslie_Roos@cpe.umanitoba.ca
Dr. Leslie Roos was the co-founder of the Manitoba Centre for Health Policy. He was named a Distinguished Professor at the University of Manitoba in 2006. For almost 30 years Dr. Roos has worked to create an information-rich environment in Manitoba to facilitate the study of health and health care. His leadership in developing the Concept Dictionary - a web-based systematic approach to sharing working knowledge - was recognized by the Lupina Foundation with a five year $625,000 award. With approximately 50,000 hits per month from several thousand investigators/students worldwide. Dr. Roos has put the University of Manitoba at the forefront of research knowledge transfer.
Noralou P. Roos, PhD
Professor
Community Health Sciences
Noralou_Roos@cpe.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Noralou Roos was the founding director of the Manitoba Centre for Health Policy and led the creation of a population database for understanding why some people are healthy and others are not. She received CFI funding to create Canada's first data laboratory, containing population based data on health, education and social services and held a Tier 1 Canada Research Chair. Citations to Dr. Roos' work place her among the top 100 Canadian scientists according to The Institute of Scientific Information. She was a member of the Prime Minister's National Forum on Health, the Interim Governing Council setting up the Canadian Institutes for Health Research, received the Order of Canada and has recently joined the Board of the United Way. She currently leads the Canadian Drug Policy Development Coalition working with Health Canada and the provinces to establish The Drug Safety and Effectiveness Network. She has also been working with community groups, business and government to bring research on At-Risk kids to the policy table.
Daniel Rothman, PhD
Assistant Professor
Clinical Health Psychology
Daniel@fps-ea.com
Accepting Graduate Students
Open for Collaboration
Factors that enhance treatment responsivity in adolescents and adults with sexual and violent behavior problems.
Autism Spectrum Disorders and sexual behavior problems - assessment and treatment.
Ethan Rubinstein, MD, L.L.b
Professor
Medical Microbiology, Internal Medicine
rubinste@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
Etiology of diarrheal diseases in various populations, MRSA infections and their treatment, Anthrax.
David N. Rush, MD, FRCPC, FACP, FASN
Professor/Head
Internal Medicine/Section of Nephrology
drush@hsc.mb.ca
Open for Collaboration
Clinical-pathological correlation in renal transplantation. Non-invasive diagnosis in renal transplantation.
Brian J. Schmidt, MD, BSc, FRCP(C), (Neurology)
Professor
Internal Medicine, Physiology
brian@scrc.umanitoba.ca
As a member of the Spinal Cord Research Group, in the Department of Physiology, my laboratory has been investigating spinal locomotor mechanisms that produce walking, using an in vitro neonatal rat spinal cord preparation. In particular, our interest focus on determining the neurotransmitter substrate and regional distribution of the locomotor network, the role of propriospinal systems in transmitting the brainstem locomotor command signal, and intrinsic membrane properties of locomotor network-related neurons. Techniques include intracellular recordings using blind whole-cell patch methods, extracellular monitoring of ventral root or peripheral nerve activity, brainstem activation of the locomotor command signal, and monitoring the effect of locomotion of selected spinal cord lesions.
Robert J. Schroth, DMD, MSc, Core Curriculum Certficate - Cdn Child Health Clinician Scientist Program
Assistant Professor
Preventative Dental Science & Pediatrics & Child Health
umschroth@cc.umanitoba.ca
Open for Collaboration
Dr. Schroth's main research interests include Early Childhood Caries (ECC), the role that nutrition and prenatal factors have on infant and preschool oral health and vitamin D. Two major studies are investigating the relationship between vitamin D deficiencies and both enamel hypoplasia and ECC in an urban Aboriginal population. He has also been involved in other ECC epidemiological work involving Aboriginal, rural and Hutterite preschool populations. Dr. Schroth is a key participant in the Healthy Smile Happy Child Project (The Manitoba Collaborative Project for the Prevention of Early Childhood Tooth Decay), a Manitoba Health grant funded project guided by the pillars of community-development, oral health promotion/education, and research/evaluation. This project has partnered wth communities to produce needed oral health promotion resources and has undertaken both quantitative and qualitative studies relating to preschool oral health in Manitoba. He also has an interest in health policy and Aboriginal health. In addition to his research program he practices part-time at 2 community clinics.
Matthew Seftel, MBChB, MPH, MRCP(UK), FRCPC
Assistant Professor
Section of Hematology/Oncology, Internal Medicine
mseftel@cancercare.mb.ca
Accepting Graduate Students
Open for Collaboration
Clinical trials in hematological malignancy, blood and marrow transplantation (BMT)
Cancer Epidemiology
Health Outcomes in Hematology/Oncology/BMT
Elizabeth A. C. Sellers, MD, MSc, BSc, FRCPC
Assistant Professor
Pediatrics and Child Health
esellers@hsc.mb.ca
Accepting Graduate Students
Open for Collaboration
My current research focuses on the emerging of type 2 diabetes in children and youth with an emphasis on First Nation populations. We are exploring issues related to the risk factors, natural history and complications, lipid abnormalities, treatment and prevention strategies for type 2 diabetes in youth. Ongoing work focuses on the cardiovascular health of this vunerable group and on specific genetic polymorphisms (HNF-1 alpha G319S) associated with early onset type 2 diabetes.
Gustaaf Sevenhuysen, PhD
Associate Professor
Community Health Sciences
gust@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
The underlying question to many of the research activities is "why do people eat what they eat"? Projects relate to documenting the reasons for food choice and developing methodologies for data collection and analysis. Related work tries to understand more general health behaviours in various patient groups.
Internationally, the health behaviour of women has been studied in an attempt to improve the effectiveness of preventive services related to MCH services in Indonesia without increasing the budget allocations for health. The food purchasing behaviour of poor people has been studied to help in the formulation eligibility criteria for public assistance in poverty alleviation initiatives and social safety nets.
Meenu K. Sharma, PhD
Adjunct Professor
Medical Microbiology
meenu_sharma@phac-aspc.gc.ca
Accepting Graduate Students
Open for Collaboration
The NRCM/NML/PHAC is a Containment Level 3 laboratory. The program provides esoteric diagnostic and surveillance services to the provincial laboratories. NRCM also promotes basic research and training.
My research aims are:
a) To conduct a detailed and systematic investigation of M. tuberculosis (M. tb) isolates and their cytokine responses to infection and to better understand mycobacterial virulence mechanisms. Our survival studies in mouse models have confirmed existence of one virulent M. tb strain in Manitoba.
b) Characterization of the differences in the protein profiles between M. tb strains will provide a better understanding of the role of mycobacterial virulence determinants.
Gary Shen, MD, PhD, MSc, BSc
Professor
Internal Medicine, Physiology
gshen@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
My research program has been supported by CIHR, Can Diabetes Assoc, and Heart Stroke Foundation of Canada. My current research interests include:
1. Regulatory mechanism for lipoproteins-induced thrombotic factors in vascular endothelial cells.
2. Diabetes-associated metabolic factors on vasuclar dysfunction.
3. Development of new antithrombotic drugs.
4. Mechanism for cardiovascular protective effects of statins.
5. Mechanism for renal protective effects of angiotensin antagonists.
6. Community study using exercise and dietary intervention in pregnant women to prevent obesity and diabetes in mothers and their offspring.
Robert Shiu, PhD
Professor
Physiology, Manitoba Institute of Cell Biology
rshiu@cc.umanitoba.ca
Open for Collaboration
Characterization of genes and molecular pathways in human breast cancer leading to bone resorption upon metastasis.
Shahin Shooshtari, PhD, MSPH, BSc
Assistant Professor
Community Health Sciences
shooshta@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
As a community health scientist, I am interested in assessing the health of populations and communities to identify their health needs and priorities. In particular, I am interested in the health and well-being of older adults and their families as well as those with life-long developmental disabilities. My research primarily uses quantitative research methods and involves the use of data from large-scale National Population Health Surveys conducted by Statistics Canada or provincial administrative databases to investigate the social, psychological and lifestyle factors associated with the development of chronic health conditions such as dementia and diabetes as well as patterns of health and health care use. My current research projects focus on "Aging with A Developmental Disability: Exploring Unmet Health and Social Services Use"; "Trajectories in Health and Social Services Use by Children with Developmental Disabilities" and "Knowledge Translation". I am also interested and conducted research in developing countries as relates to mental health and disabilities.
Louise R. Simard, PhD
Professor & Head
Biochemistry & Medical Genetics
louise_simard@umanitoba.ca
Accepting Graduate Students
Open for Collaboration
The major focus of my research concerns Spinal Muscular Atrophy (SMA), the most common monogenic cause of early infant death. SMA is caused by mutations in the survival motor neuron (SMN) gene, resulting in motor neuron loss and muscle atrophy. Severe type 1 SMA infants generally die within he first two years of life due to respiratory failure. My laboratory has made important contributions in the area of SMA genetics and translating this knowledge to DNA diagnostics. We were among the first groups to demonstrate that SMN protein is very abundant in axonal growth cones, suggestive of a neuronal-specific function. We are providing "biomarker" data to follow the efficacy of HDAC inhibitors currently used in SMA clinical trialsor "novel" chemical compounds being tested in SMA animals by various research groups. Finally, we have an active research program aimed at understanding the mechanisms by which SMN gene expression is regulated to identify new therapeutic targets that would make more SMN protein available to SMA proteins.
F. Estelle R. Simons, BSc, MD, FRCPC
Professor and Head, Section of Allergy & Clinical Immunology
Pediatrics & Child Health, Immunology
Open for Collaboration
Open for Commercialization
Innovative investigator-initiated studies of the clinical pharmacology of medications used in the treatment of allergic disorders, including: development of new epinephrine dosage forms for treatment of anaphylaxis. Development of recombinant vaccines for skin testing and allergen-specific immunotherapy in mosquito-allergic individuals. Longitudinal studies of cytokine and chemokine production by allergic and healthy individuals in response to environmental and dietary allergens.
Pawan K. Singal, MSc, PhD, DSc
Professor & Director
Physiology, St. Boniface Hospital Research Centre
psingal@sbrc.ca
Accepting Graduate Students
Open for Collaboration
Our laboratory initiated and has the continued interest in describing the role of oxidative stress in heart cell pathophysiology. Currently, we are examining different signalling pathways in adriamycin-induced heart failure and cytokine changes and their significance in the pathogenesis of heart failure subsequent to myocardial infarction.
YL Chris Siow, PhD, BSc(Hon)
Adjunct Professor
Physiology, CCARM
Chris_Siow@umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Abnormalities in cell signalling pathways have been demonstrated in many diseases, including cardiovascular disease. Compounds that intervene at these abnormal signalling processes represent a novel type of therapy. Agri-food and natural products including herbal medicine are known to have beneficial effects for the heart. The molecular mechanisms underlying their actions are still being defined. The primary objective of our research is to study the biochemical and molecular mechanisms of herbal medicinal compounds and natural health products, and horticultural products focusing on signalling pathways in cardiovascular disease.
Lab's Mission: The gateway to cardiovascular health is through the action of herbal compounds on components of the human kinome.
Daniel S. Sitar, FCP, PhD, Licensed Pharmacist, MSc, BScPharm
Professor
Pharmacology & Therapeutics, Internal Medicine, Pediatrics
sitar@cc.umanitoba.ca
Open for Collaboration
Open for Commercialization
The focus of our research is to optimize drug therapy for patients at the extremes of age. Our fundamental research is in the areas of drug metabolism, renal tubular transport and identification of therapeutic targets for the drug therapy of Alzheimer's disease. We hold a patent on a new diagnostic test for cancer, and we are continuing to determine the types and stages of the disease that it will detect. Our clinical research studies relate to pharmacokinetic investigations of opioid and nonopioid analgesics, antibiotics, and antiviral agents, interventions that reduce the morbidity and mortality of drug overdoses, and evaluation of adherence to prescribed therapy. Our laboratory techniques focus primarily on the development and use of drug and metabolite analyses in biological specimens by gas-liquid chromatography and high performance liquid chromatography. We have considerable experience with the use of tracer levels of radioisotopes as a tool to determine drug transport and for the development of assays for nonradioactive forms of drug molecules using LC/MS/MS.
Abdelilah Soussi Gouni, PhD, MSc, BSc
Associate Professor
Immunology
gounni@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
My research program investigates the mechanisms regulating airway inflammation of allergic asthma and chronic obstructive pulmonary disease (COPD). In particular, we are focusing on the role of IgE, glucocorticoids and cytokines in these events.
Ongoing research projects:
- The molecular basis of IgE/FceRI mediated human neutrophil survival in asthma by studying the role of Bcl-2 family protein, caspass, and IAPs on this process, as well the cross talk between FceRI early and downstream signaling events.
- The function of TSLP and TSLPR in chronic obstructive pulmonary disease airway inflammation.
- The signaling pathway of IL-9 and IL-17 receptor mediated airway smooth muscle activation.
Newman L. Stephens, MBBs, MD, FRCP
Professor
Physiology and Pediatrics
nstephe@ms.umanitoba.ca
Open for Collaboration
My research deals with the ultrastructure, biophysics and biochemistry of airway smooth muscle contraction under physiological and pathophysiological (Asthma) conditions. We use molecular biological approaches to elucidate pathogenesis.
Theresa M. Sullivan, BSc (OT), MA, OT Reg. (MB)
Assistant Professor
Occupational Therapy
tsulliv@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
My research interests lie in three primary areas:
1) Health professional and patient education. I am developing academic and clinical health professional curriculum and examining the effectiveness of various teaching and learning strategies for both students and patients/clients.
2) Clinical/Professional reasoning. I am examining the reasoning methods used by therapists in practice and the development of educational tools and strategies to assist students in their reasoning development.
3) Professional development. I am developing a model that describes student occupational therapists professional development throughout their professional program.
Shayne P. Taback, MD, FRCPC
Associate Professor
Pediatrics & Child Health, Community Health Sciences
tabacksp@cc.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Areas
1. Prevention of type 1 diabetes
2. Pediatric osteoporosis
Methods
1. Clinical epidemiology and clinical trials
2. Meta-analysis
James Tam, MD, FRCP(C), FACC
Associate Professor
Medicine
jtam@sbgh.mb.ca
Open for Collaboration
I have been working on a number of studies evaluating the role of the physical examination as well as the clinical utility of diagnostic cardiac testing such as echocardiography and its impact on patient care as well as health care utilization and resource management. In addition, I am also involved in various multicentred clinical trials in the areas of congestive heart failure, vascular protection, hypertension and dyslipidemia.
Robert B. Tate, PhD, MSc, BSc
Associate Professor
Community Health Sciences
tate@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
The Manitoba Follow-up Study has been housed within the Faculty of Medicine at the University of Manitoba since its inception on July 1, 1948. Routine medical examinations have been collected from this cohort of 3,983 young, male, air crew recruits to the RCAF during WWII. A main focus has been to study the natural development of cardiovascular disease. The study continues today, with about 1,200 of the original cohort still alive, now at a mean age of 85 years. 93% live in Canada and the remainder in other countries around the world. We continue to contact study members twice yearly. Recently research interest has expanded to explore aspects of mental, physical and social functioning, as well as to understand the process of healthy and successful aging. More information about the Manitoba Follow-up Study can be found at http://www.mfus.ca/.
Michael Teschuk, PhD, CPsych
Assistant Professor
Clinical Health Psychology
mteschuk@hsc.mb.ca
Open for Collaboration
Treatment effectiveness/outcome for pediatric encopresis.
Pediatric neuropsychology
Graham Tipples, PhD
Adjunct Professor
Medical Microbiology
graham_tipples@hc-sc.gc.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
Dr. Tipples is the Director of Surveillance and Reference Services and the Head of the Viral Exanthemata Section at the National Microbiology Laboratory, Public Health Agency of Canada. His lab activities include diagnostics, surveillance and research on viruses which cause rash illness in humans, such as measles, rubella, varicella-zoster, and human herpes virus 6.
Mark G. Torchia, PhD, MSc
Associate Professor
Surgery, Human Anaomty and Cell Science
markt@sbrc.ca
Open for Collaboration
Open for Commercialization
Minimally invasive diagnosis and treatment; Image guided surgery; Novel MRI contrast agents; MRI as a measure of angiogenesis.
Barbara Triggs-Raine, PhD
Professor
Biochemistry & Medical Genetics
traine@ms.umanitoba.ca
Accepting Graduate Students
Open for Collaboration
Open for Commercialization
My research interests centre around understanding the molecular basis and pathogenesis of human genetic disorders. Building on our earlier discovery - that a defect in hyaluronidase 1 causes Mucopolysaccharidosis IX (MPS IX)- we began characterizing how the family of hyaluronidase enzymes coordinate to break down and regulate the function of hyaluronan. Mouse models deficient in individual hyaluronidases have been developed and these serve as tools to investigate the roles of these enzymes in degrading hyaluron while providing a model for the disorder that results from its deficiency. Knockout mice for each of the individual hyaluronidases have unique phenotypes that we are now characterizing, including the Hyal 1 (MPS IX model) deficient mice which exhibit premature proteoglycan loss and osteoarthritis. Our laboratory is also involved in a group project aimed at characterizing the basis of Bowen Conradi Syndrome (BCS). A candidate gene for this disorder has been identified and we are determining how this change could lead to the phenotype of BCS.
Donna Turner, PhD
Assistant Professor
Community Health Sciences
donna.turner@cancercare.mb.ca
Accepting Graduate Students
Open for Collaboration
Dr. Turner is a cancer epidemiologist whose primary appointment is with CancerCare Manitoba. Her research revolves around the use of population-based cancer data, particularly cancer registries and linked administrative data (information collected as part of the management of health care insurance plans or employment) for surveillance and cancer control. Her current position allows her to work in various aspects of cancer control research - from prevention/etiology to early detection, diagnosis and treatment outcomes - using the unique population-based data resources available in Manitoba.