Department of Anesthesia Publications
Department of Anesthesia, University of Manitoba
Recent Publications (2010 to 2013)

Algurashi F, Ong B, Unruh H. Hemodynamic, respiratory, and fluid volume changes with bronchopulmonary lavage. J Clin Anesth. 2011 Nov;23(7):594-6.

Ali AA, White P, Xiang B, Lin HY, Tsui SS, Ashley E, Lee TW, Klein JR, Kumar K, Arora RC, Large SR, Tian G, Freed DH. Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs. Am J Transplant. 2011 Aug;11(8):1621-32.

Almoustadi WA, Lee TW, Klein J, Kumar K, Arora RC, Tian G, Freed DH. The effect of total spinal anesthesia on cardiac function in a large animal model of brain death. Can J Physiol Pharmacol. 2012 Sep;90(9):1287-93.

Amadeo R, Sutherland E. Chronic pain: from wait lists to rehabilitation, a clinical report of the Manitoba perspective. Can J Anaesth. 2010 Apr 57(4):385-6.

Arenson BG, Macdonald LA, Grocott HP, Hiebert BM, Arora RC. Effect of intensive care unit environment on in-hospital delirium after cardiac surgery. J Thorac Cardiovasc Surg. 2013 Jul;146(1):172-8.

Ariano RE, Duke PC, Sitar DS. The influence of sparse data sampling on population pharmacokinetics: a post hoc analysis of a pharmacokinetic study of morphine in healthy volunteers. Clin Ther. 2012 Mar;34(3):668-76.

Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, et al. Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med. 2011 Aug 18;365(7):591-600.

Avidan MS, Palanca BJ, Glick D, Jacobsohn E, Villafranca A, O'Connor M, Mashour GA; BAG-RECALL Study Group. Protocol for the BAG-RECALL clinical trial: a prospective, multi-center, randomized, controlled trial to determine whether a bispectral index-guided protocol is superior to an anesthesia gas-guided protocol in reducing intraoperative awareness with explicit recall in high risk surgical patients. BMC Anesthesiol 2011 ;9:8.

Avidan MS, Smith JR, Skrupky LP, Hill L, Jacobsohn E, Burnside B, Tymkew H, Eby C, Damiano R, Despotis GJ. The occurrence of antibodies to heparin-platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis. Thromb Res. 2011 Dec;128(6):524-9.

Baron CM, Swedlo D, Funk DJ. Minimally invasive cardiac output monitoring for a parturient with pulmonary hypertension. Int J Obstet Anesth. 2013 Jan;22(1):78-80.

Baron CM, Girling LG, Mathieson AL, Menticoglou, SM, Seshia, MM, Cheang, MS, Mutch WA. Obstetrical and neonatal outcomes in obese parturients. J Mat-Fetal Neonatal Med 2010 Aug 23:906-13.

Benson EE, McMillan DE, Ong B. The effects of active warming on patient temperature and pain after total knee arthroplasty. Am J Nurs. 2012 May;112(5):26-33.

Bokesch PM, Szabo G, Wojdyga R, Grocott HP, Smith PK, David Mazer C, Vetticaden S, Wheeler A, Levy JH. A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovasc Surg. 2011 Jul 1. [Epub ahead of print].

Bottle A, Mozid A, Grocott HP, Walters MR, Lees KR, Aylin P, Sanders RD. Preoperative risk factors in 10 418 patients with prior myocardial infarction and 5241 patients with prior unstable angina undergoing elective coronary artery bypass graft surgery. Br J Anaesth. 2013 Apr 16. [Epub ahead of print]

Bottle A, Mozid A, Grocott HP, Walters MR, Lees KR, Aylin P, Sanders RD. Preoperative stroke and outcomes after coronary artery bypass graft surgery. Anesthesiology. 2013 Apr;118(4):885-93.

Brinkman R, Amadeo RJ, Funk DJ, Girling LG, Grocott HP, Mutch WA. Cerebral oxygen desaturation during one-lung ventilation: correlation with hemodynamic variables. Can J Anaesth. 2013 Jul;60(7):660-666.

Burwash IG, Basmadjian A, Bewick D, Choy JB, Cujec B, Jassal DS, MacKenzie S, Nair P, Rudski LG, Yu E, Tam JW. 2010 Canadian Cardiovascular Society/Canadian Society of Echocardiography Guidelines for Training and Maintenance of Competency in Adult Echocardiography. Can J Cardiol. 2011 Nov-Dec;27(6):862-4.

Calvi CL, Lynch J, Grocott HP. Longitudinal assessment of neurocognitive function in rats after cardiopulmonary bypass: evidence for long-term deficits. J Cardiothorac Vasc Anesth. 2010 Apr;24(2):293-9.

Choinière M, Dion D, Peng P, Banner R, et al. The Canadian STOP-PAIN project - Part 1: who are the patients on the waitlists of multidisciplinary pain treatment facilities? Can J Anaesth. 2010 Jun;57(6):539-48. (Co-Author: H. Intrater)

Chowdhury T, Cappellani RB, Schaller B; for Trigeminocardiac Reflex Examination Group (TCREG). Retrogasserian glycerol rhizolysis: first description of occurrence trigeminocardiac reflex. J Neurosurg Anesthesiol. 2013 May 16. [Epub ahead of print]

Chowdhury T, Cappellani RB. Extubation time in neurosurgical patients: does it matter? J Anesth. 2013 Jun;27(3):476.

Chowdhury T, Cappellani RB. Isolated bradycardia due to skull pin fixation: raised ICP or TCR? J Neurosurg Anesthesiol. 2013 Apr;25(2):207.

Chowdhury T, Cappellani RB. Role of fentanyl in supratentorial tumor: can it change the requirement of propofol? J Neurosurg Anesthesiol. 2013 Apr;25(2):208.

Chowdhury T, Wilkinson MF, Krcek JP. A transient acute neurological event in a patient undergoing GPI microelectrode mapping: diagnostic dilemma. J Neurosurg Anesthesiol. 2013 Apr;25(2):212.

Chowdhury T, West M. Intraoperative asystole in a patient undergoing craniotomy under monitored anesthesia care: is it TCR? J Neurosurg Anesthesiol. 2013 Jan;25(1):92-3.

Chowdhury T, Cappellani RB, Daya J. Neuroanesthetic considerations for emergent extracranial surgeries: what to know? Saudi J Anaesth. 2012 Oct-Dec;6(4):408-11.

Chowdhury T, Bharati SJ. Severe bradycardia during laryngoscopy in adult neurosurgical patient. Saudi J Anaesth. 2012 Jul;6(3):308.

Dart AB, Mutter TC, Ruth CA, Taback SP. Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007594.

Davie SN, Grocott HP. Impact of extracranial contamination on regional cerebral oxygen saturation: a comparison of three cerebral oximetry technologies. Anesthesiology. 2012 Apr;116(4):834-40.

Denault AY, Haddad F, Jacobsohn E, Deschamps A. Perioperative right ventricular dysfunction. Curr Opin Anaesthesiol. 2013 Feb;26(1):71-81.

Denault AY, Tardif JC, Mazer CD, Lambert J; BART Investigators. Difficult and complex separation from cardiopulmonary bypass in high-risk cardiac surgical patients: a multicenter study. J Cardiothorac Vasc Anesth. 2012 Aug;26(4):608-16. (Collaborator: P.C. Duke)

Dzik WH, Blajchman MA, Fergusson D, Hameed M, Henry B, Kirkpatrick AW, Korogyi T, Logsetty S, Skeate RC, Stanworth S, MacAdams C, Muirhead B. Clinical review: Canadian National Advisory Committee on Blood and Blood Products--Massive transfusion consensus conference 2011: report of the panel. Crit Care. 2011;15(6):242.

Espenell AE, Gulati H, McIntyre IW, Girling LG, Silvaggio JA, Koulack J, Harding GEJ, Kaufmann AM, Wilkinson MF, Mutch WA. Point-of-care monitoring during carotid endarterectomy under general anesthesia: correlations between lactate flux and cerebral oximetry. Can J Anaesth. 2010 Oct 57:903-12.

Fedorow CA, Moon MC, Mutch WA, Grocott HP. Lumbar cerebrospinal fluid drainage for thoracoabdominal aortic surgery: rationale and practical considerations for management. Anesth Analg. 2010 Jul 111:46-58.

Federow C and Grocott HP. Cerebral monitoring to optimize outcomes after cardiac surgery. Curr Opin Anaesthesiol. 2010 Feb;23(1):89-94.

Flu WJ, van Kuijk JP, Hoeks SE, Kuiper R, Schouten O, Goei D, Elhendy A, Verhagen HJ, Thomson IR, Bax JJ, Fleisher LA, Poldermans D. Prognostic implications of asymptomatic left ventricular dysfunction in patients undergoing vascular surgery. Anesthesiology. 2010 Jun;112(6):1316-24.

Fritz BA, Rao P, Mashour GA, Abdallah AB, Burnside BA, Jacobsohn E, Zhang L, Avidan MS. Postoperative recovery with bispectral index versus anesthetic concentration-guided protocols. Anesthesiology. 2013 May;118(5):1113-22.

Funk DJ, Kumar A. If the Central Venous Pressure Is [x], Call Me … Maybe*. Crit Care Med. 2013 Jul;41(7):1823-4.

Funk DJ, Kumar A. Inhaled nitric oxide in patients with the acute respiratory distress syndrome secondary to the 2009 influenza A (H1N1) infection in Canada. Can J Anaesth. 2013 Feb;60(2):212-3.

Funk DJ, Jacobsohn E, Kumar A. Role of the venous return in critical illness and shock: Part II: shock and mechanical ventilation. Crit Care Med. 2013 Feb;41(2):573-9.

Funk DJ, Jacobsohn E, Kumar A. The role of venous return in critical illness and shock-Part I: physiology. Crit Care Med. 2013 Jan;41(1):255-62.

Funk DJ, Kumar A. Antimicrobial therapy for life-threatening infections: speed is life. Crit Care Clin. 2011 27(1):53-76.

Funk DJ. The use of recombinant human activated protein, Vargas, JP, Tuttle-Newhall J, Moretti EW. C (Drotrecogin alpha) in solid organ transplant recipients: Case series and review of the literature. Transplant Infectious Disease 2011 Dec;13(6):592-7.

Funk DJ, Siddiqui F, Wiebe K, Miller RR 3rd, Bautista E, Jimenez E, Webster K, Kumar A. Practical lessons from the first outbreaks: clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis. Crit Care Med. 2010 Apr;38(4 Suppl):e30-7.

Graham MR, Gulati H, Kha L, Girling LG, Goertzen A, Mutch WA. Resolution of pulmonary edema with variable mechanical ventilation in a porcine model of acute lung injury. Can J Anaesth. 2011 Aug;58(8):740-50.

Graham MR, Goertzen AL, Girling LG, Friedman T, Pauls RJ, Dickson T, Espenell AE, Mutch WA. Quantitative computed tomography in porcine lung injury with variable versus conventional ventilation: recruitment and surfactant replacement. Crit Care Med. 2011 Jul;39(7):1721-30.

Grocott HP, Davie SN. Cerebral oximetry determination of desaturation with norepinephrine administration may be device manufacturer specific. Anesthesiology 2013 Apr;118(4):982.

Grocott HP, Andreiw A. Con: topical head cooling should not be used during deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth. 2012 Apr;26(2):337-9.

Grocott HP. Blood pressure during cardiopulmonary bypass: how low is too low? Anesth Analg. 2012 Mar;114(3):488-90.

Grocott HP. Monitoring the brain in cardiac surgery--an evolving area for research. Anaesthesia. 2012 Mar;67(3):216-9.

Grocott HP. Avoid hypotension and hypoxia: an old anesthetic adage with renewed relevance from cerebral oximetry monitoring. Can J Anaesth. 2011 Aug;58(8):697-702.

Grocott HP, Gulati H, Srinathan S, Mackensen GB. Anesthesia and the patient with pericardial disease. Can J Anaesth. 2011 Oct;58(10):952-966.

Grocott HP, Davie S, Fedorow C. Monitoring of brain function in anesthesia and intensive care. Curr Opin Anaesthesiol. 2010 Dec;23(6):759-64.

Grocott HP, Tran T. Aortic atheroma and adverse cerebral outcome: risk, diagnosis, and management options. Semin Cardiothorac Vasc Anesth. 2010 Jun;14(2):86-94.

Guerriere DN, Choinière M, Dion D, Peng P et al. The Canadian STOP-PAIN project - Part 2: what is the cost of pain for patients on waitlists of multidisciplinary pain treatment facilities? Can J Anaesth. 2010 Jun;57(6):549-58. (Co-Author: H. Intrater)

Hall R, Beattie S, Cheng D, Choi P, Denault AY, Mazer D, Mutch WA, Turgeon AF, Yang H. Can we develop a Canadian Perioperative Anesthesiology Clinical Trials group? Can J Anaesth. 2010 Dec;57(12):1051-7.

Homi HM, Sheng H, Arepally GM, Mackensen GB, Grocott HP. Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass. Anesth Analg. 2010 Jul;111(1):38-45.

Homi HM, Jones WL, de Lange F, Mackensen GB, Grocott HP. Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. J Thorac Cardiovasc Surg 2010 Sep;140(3):660-6, 666.e1.

Homi HM, Calvi CL, Lynch J, Grocott HP. Longitudinal assessment of neurocognitive function in rats after cardiopulmonary bypass: evidence for long-term deficits. J Cardiothorac Vasc Anesth. 2010 Apr;24(2):293-9.

Karlstedt E, Chelvanathan A, Da Silva M, Cleverley K, Kumar K, Bhullar N, Lytwyn M, Bohonis S, Oomah S, Nepomuceno R, Du X, Melnyk S, Zeglinski M, Ducas R, Sefidgar M, Mackenzie S, Sharma S, Kirkpatrick ID, Jassal DS. The impact of repeated marathon running on cardiovascular function in the aging population. J Cardiovasc Magn Reson. 2012 Aug 20;14:58.

Kertai MD, Pal N, Palanca BJ, Lin N, Searleman SA, Zhang L, Burnside BA, Finkel KJ, Avidan MS: B-Unaware Study Group. Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial. Anesthesiology. 2010 May;112(5):1070-2. (Collaborator: E. Jacobsohn)

Kertai MD, Pal N, Palanca BJ, Lin N, Searleman SA, Zhang L, Burnside BA, Finkel KJ, Avidan MS; B-Unaware Study Group. Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial. Anesthesiology. 2010 May;112(5):1116-27. (Collaborator: E. Jacobsohn)

Kumar K, Nepomuceno RG, Chelvanathan A, Golian M, Bohonis S, Cleverley K, Ravandi A, Mackenzie S, Jassal DS. The role of tissue Doppler imaging in predicting left ventricular filling pressures in patients undergoing cardiac surgery: an intraoperative study. Echocardiography. 2013 Mar;30(3):271-8.

Lin Y, Moltzan CJ, Anderson DR; National Advisory Committee on Blood and Blood Products. The evidence for the use of recombinant factor VIIa in massive bleeding: revision of the transfusion policy framework. Transfus Med. 2012 Dec;22(6):383-94. (Collaborator: B. Muirhead)

Lin HY, Freed D, Lee TW, Arora RC, Ali A, Almoustadi W, Xiang B, Wang F, Large S, King SB, Tomanek B, Tian G. Quantitative assessment of cardiac output and left ventricular function by noninvasive phase-contrast and cine MRI: validation study with invasive pressure-volume loop analysis in a swine model. J Magn Reson Imaging. 2011 Jul;34(1):203-10.

Littleford J, Gottschalk T. The medical student's Toolkit. Med Educ. 2012 Nov;46(11):1117.

Manji RA, Grocott HP, Leake J, Ariano RE, Manji JS, Menkis AH, Jacobsohn E. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anaesth. 2012 Jan;59(1):6-13.

Mitchell RT, Funk D, Spiwak R, Logsetty, S. Phenylephrine tumescence in split-thickness skin graft donor sites in surgery for burn injury - a concentration finding study. J Burn Care Res 2011 32(1):129-34.

Mutch WA. Allometry and physiologic time: Comment on "Physiologic time: A hypothesis" by West & West. Phys Life Rev. 2013 Jun;10(2):229-30.

Mutch WA, Patel SR, Shahidi AM, Kulasekara SI, Fisher JA, Duffin J, Hudson C. Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia. PLoS One. 2013;8(2):e57881.

Mutch WA, Mandell DM, Fisher JA, Mikulis DJ, Crawley AP, Pucci O, Duffin J. Approaches to brain stress testing: BOLD magnetic resonance imaging with computer-controlled delivery of carbon dioxide. PLoS One. 2012;7(11):e47443.

Mutch WA. Academic fraud: perspectives from a lifelong anesthesia researcher. Can J Anaesth. 2011 Sep;58(9):782-788.

Mutch WA, Fransoo RR, Campbell BI, Chateau DG, Sirski M, Warrian RK. Dementia and depression with ischemic heart disease: a population-based longitudinal study comparing interventional approaches to medical management. PLoS ONE 2011 Feb 28;6(2):e17457.

Mutch WA. New concepts regarding cerebral vasospasm: glial-centric mechanisms. Can J Anaesth, 2010 May 57:479-89.

Olafson K, Ramsey CD, Ariano RE, Stasiuk A, Siddiqui F, Wong D, Guinn A, Braun J, Kumar A, Zarychanski R. Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias. Ann Pharmacother. 2012 Jan;46(1):9-20.

Qing M, Shim JK, Grocott HP, Sheng H, Mathew JP, Mackensen GB. The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2011 Aug;142(2):424-9.

Sanders RD, Grocott HP. Perioperative stroke: time to redefine the impact of age? Stroke. 2012 Jan;43(1):3-5.

Strumpher J, Jacobsohn E. Pulmonary hypertension and right ventricular dysfunction: physiology and perioperative management. J Cardiothorac Vasc Anesth. 2011 Aug;25(4):687-704.

Tsui AK, Dattani ND, Marsden PA, El-Beheiry MH, Grocott HP, Liu E, Biro GP, Mazer CD, Hare GM. Reassessing the risk of hemodilutional anemia: some new pieces to an old puzzle. Can J Anaesth. 2010 Aug;57(8):779-91.

Villafranca A, Thomson IA, Grocott HP, Avidan MS, Kahn S, Jacobsohn E. The impact of bispectral index versus end-tidal anesthetic concentration-guided anesthesia on time to tracheal extubation in fast-track cardiac surgery. Anesth Analg. 2013 Mar;116(3):541-8.

Villafranca AJ, Arenson BG, Avidan MS, Glick D, Mashour GA, Jacobsohn E. Case report: volitional delay of self-reported outcomes: insights from a case of intraoperative awareness with explicit recall. Anesth Analg. 2013 Feb;116(2):365-7.

Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA. 2012 Jun 6;307(21):2295-304. (Collaborators: R. Amadeo, D. Funk, H.P. Grocott, T.W. Lee, H. McDonald, F. Siddiqui)

Wallbridge HR, Benoit AG, Staley D, Ediger JP, Campbell BI. Risk factors for postoperative cognitive and functional difficulties in abdominal aortic aneurysm patients: a three month follow-up. Int J Geriatr Psychiatry. 2011 Aug;26(8):818-24.

Whitlock EL, Villafranca AJ, Lin N, Palanca BJ, Jacobsohn E, Finkel KJ, Zhang L, Burnside BA, Kaiser HA, Evers AS, Avidan MS. Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology. 2011 Dec;115(6):1209-18.

Zubert S, Funk DJ, Kumar A. Antibiotics in sepsis and septic shock: like everything else in life, timing is everything. Crit Care Med. 2010 Apr;38(4):1211-2.