Journal Club takes place every Monday from 11:00 - 12:15 p.m. in the Alec Sehon Suite, 4th Floor, Apotex Centre.
Attendance is taken at Journal Club meetings. Please remember to sign in on the sheet provided before the meeting begins.
Journal Club presentations are required as part of your graduate program. If your presentation date is not workable, arrange to switch dates with another student and inform Dr. Aaron Marshall (Faculty Journal Club Co-ordinator) and the General Office staff. You cannot skip making a presentation.
Journal Club Presenters must send their article title and abstract (NOT the article itself) to Karen Morrow (Immunology Dept. Administrative Assistant) ONE WEEK PRIOR TO THEIR PRESENTATION DATE. Make sure to include THE FULL CITATION (Journal name, volume, date, and page numbers.)
***Presenters: See Instructions for Journal Club Presentations****
| September 2013 | October | November | December |
January 2014 |
| February | March | April | May | June |
| Last year's Journal Club Schedule | ||||
September Co-ordinator: Hesam Movassagh
September 9 - Trainee Meeting and GSA Election
12:00 noon
Alec Sehon Seminar Room
4th Floor Apotex Centre
September 16 - Rebecca Dielschneider
Article:
McEwan WA, Tam JC, Watkinson RE, Bidgood SR, Mallery DL, James LC. Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol. 2013;14(4):327-36. doi: 10.1038/ni.2548.
Abstract:
During pathogen infection, antibodies can be carried into the infected cell, where they are detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we found that recognition of intracellular antibodies by TRIM21 activated immune signaling. TRIM21 catalyzed the formation of Lys63 (K63)-linked ubiquitin chains and stimulated the transcription factor pathways of NF-κB, AP-1, IRF3, IRF5 and IRF7. Activation resulted in the production of proinflammatory cytokines, modulation of natural killer stress ligands and induction of an antiviral state. Intracellular antibody signaling was abrogated by genetic deletion of TRIM21 and was restored by ectopic expression of TRIM21. The sensing of antibodies by TRIM21 was stimulated after infection by DNA or RNA nonenveloped viruses or intracellular bacteria. Thus, the antibody-TRIM21 detection system provides potent, comprehensive activation of the innate immune system independently of known pattern-recognition receptors.
September 23 - Jyoti Balhara
Article:
Abstract:
This journal club presentation will be followed immediately by:
Department Annual Safety Meeting
Speaker: Dr. Abdel Soussi Gounni, Safety Officer
NOTE: Attendance is COMPULSORY for all lab personnel - students, Post Docs, Research Associates and Technicians
September 30 - Research in Progress
Cancelled - No seminar today
October Co-ordinator: Fazle Rabbi
October 7 - Research in Progress
Dr. Cynthia Guidos
Senior Scientist, Program in Developmental & Stem Cell Biology
Scientific Director, SickKids-UHN Flow Cytometry Facility
Hospital for Sick Children Research Institute
TITLE TBD
Graduate Student lunch with Dr. Guidos will follow at 12:00 noon.
October 14 - Thanksgiving. University closed.
October 21 - Ibrahim Sow
Article:
Abstract:
October 28 - Hesam Movassagh
Article:
Abstract:
November Co-ordinator: Forough Khadem
November 4 - Research in Progress
November 11 - Remembrance Day. University closed.
November 18 - Nandu Anaparti
Article:
Abstract:
November 25 - Hongzhao Li
Article:
Abstract:
December Co-ordinator: Duaa Alsubait
December 2 - Research in Progress
December 9 - Chris Wiebe
Article:
Abstract:
December 16 - Deepak Upreti
Article:
Abstract:
January Co-ordinator: Vasudeva Bhat
January 6 - Research in Progress
January 13 - Shiby Kuriakose
Article:
Abstract:
January 20 - Nipun Jayachandran
Article:
Abstract:
January 27 - Forough Khadem
Article:
Abstract:
February Co-ordinator: Jyoti Balhara
February 3 - Research in Progress
February 10 - Grace Choi
Article:
Abstract:
February 17 - Louis Riel Day. University closed.
Article:
Abstract:
February 24 - Emeke Okeke
Article:
Abstract:
March Co-ordinator: Emeka Okeke
March 3 - Research in Progress
March 10 - Nonso Onyilagha
Article:
Abstract:
March 17 - Xun Wu
Article:
Abstract:
March 24 - Fazle Rabbi
Article:
Abstract:
March 31 - Hadeesha Piyadasa
Article:
Abstract:
April Co-ordinator: Shiby Kuriakose
April 7 - Research in Progress
April 14 - Vasudeva Bhat
Article:
Abstract:
April 21 - Nazanin Tatari
Article:
Abstract:
April 28 - Duaa Alsubait
Article:
Abstract:
May Co-ordinator: Nazanin Tatari
May 5 - Research in Progress
May 12 - Milind Muley
Article:
Abstract:
May 19 - Victoria Day. University closed.
May 26 - Abdulaziz Alamri
Article:
Abstract:
June Co-ordinator: Rebecca Dielschneider
June 2 - Research in Progress
June 9 - Ashfaque Mohammed
Article:
Abstract:
June 16 -
Article:
Abstract:
End of Journal Club for 2013-2014