| Course Co-ordinator: | Dr. Jude Uzonna |
| Office: | 425 Apotex Centre |
| Phone: | (204) 977-5659 |
| Email: | Jude.Uzonna@med.umanitoba.ca |
| Course Times: | Mondays and Wednesdays January 13 - April 21, 2014 9:00-11:00 a.m. (Mondays) 9:30-11:30 a.m. (Wednesdays) |
| Location: | 477 Apotex Centre, A. Sehon Seminar Room |
Objective:
To develop an in-depth understanding of the development, functioning and regulation of the mammalian immune system. This is the most advanced course in the Department of Immunology and is aimed at senior graduate students in immunology or those in related disciplines who wish an advanced perspective on immunologic knowledge and current research.
Pre-requisite:
IMMU7070 - Introductory Immunology (or equivalent) or the written permission of the course Co-ordinator. Course instructors will assume that students are familiar with immunology at the level of the Abbas textbook Basic Immunology, 2010.
Classes:
Intensive. Lectures (2 hr/lecture) will be held twice a week (Mondays, 9:00-11:00 a.m. and Wednesdays 9:30-11:30 a.m.) in room 477, the Alec Sehon Seminar Room, in the Apotex Centre building. At the discretion of the instructors, lectures may be didactic and/or paper-based discussions.
Evaluation:
This course will be graded based on a midterm (35% of the final mark), 1 take-home assignment (10%), participation in a formal "in class" debate on a topic to be assigned (10%) and a final exam mostly on the lectures given after the midterm (45%). Please note that the final exam will also include about 2 questions from lectures given prior to the midterm exam. The take-home assignment, which will be given at the end of lectures, will test students' critical thinking, analytical and synthesis abilities and will require students to design experiments (including appropriate controls) to test immunological hypotheses. Both the mid-term and final exam questions will be of the short answer style and will test students' critical and analytical skills.
Evaluation Summary:
| Midterm Exam (closed book) | 35% |
| Final Exam (closed book) | 45% |
| Take home assignment | 10% |
| In-class debate | 10% |
Class Schedule:
| Jan. 13, 2014 | Course Overview: Brief review of Immunology | J. Uzonna |
| Jan. 15 | Pattern recognition receptors and host defense peptides | N. Mookherjee |
| Jan. 20 | Dendritic cell biology | S. Kung |
| Jan. 22 | NK cells: Activating and inhibitory receptors | S. Kung |
| Jan. 27 | Haematopoesis and immunity | A. Raouf |
| Jan. 29 | Granulocyte: Ontogeny and function | A. Soussi Gounni |
| Feb. 3 | Antigen Presentation, cytotoxicity and anti-viral immunity | J. Rempel |
| Feb. 5 | Antigen receptor structure, diversity and recognition | A. Marshall |
| Feb. 10 | B cell biology | A. Marshall |
| Feb. 12 | Signalling through immune system receptors | A. Marshall |
| Feb. 17 | Louis Riel Day - University Closed | |
| Feb. 19 | Chemotaxis and homing of immune cells | F. Lin |
| Feb. 24 | Immunologic memory | J. Uzonna |
| Feb. 26 | Regulation of immune responses, costimulation, cytokines, Th1/Th2 | K. HayGlass |
| Mar. 3 | Cytokine and chemokine receptors: Structure, signaling and function | A. Soussi Gounni |
| Mar. 5 | MID-TERM EXAMINATION | |
| Mar. 10 | Vaccines/extrinsic regulation of immune responses | X. Yang |
| Mar. 12 | Epigenetic regulation of immune response | R. Su |
| Mar. 17 | Transplantation | P. Nickerson |
| Mar. 19 | Immunobiology of hemorrhagic viral infections | G. Kobinger |
| Mar. 24 | Immunobiology HIV/AIDS | B. Ball |
| Mar. 26 | Apotosis pathways and haematopoietic cancers | S. Gibson |
| Mar. 30 | Tryptophan catabolism and immune regulation | K. Orihara |
| Apr. 2 | The mucosal immune system | J. Ghia |
| Apr. 7 | Neuroimmunology | J. Ghia |
| Apr. 9 | Viral immunopathology and vaccines | S. Babiuk |
| Apr. 14 | Autoimmunity and immune deficiency states | ? |
| Apr. 16 | Immunopathology | J. Uzonna |
| Apr. 21 | DEBATE: Topics TBA | J. Uzonna |