IMMU7020 - Immunobiology
Course Outline
Winter 2014
CRN #22777 A01


DRAFT ONLY



Course Co-ordinator: Dr. Jude Uzonna
Office: 425 Apotex Centre
Phone: (204) 977-5659
Email: Jude.Uzonna@med.umanitoba.ca
Course Times: Mondays and Wednesdays
January 13 - April 21, 2014
9:00-11:00 a.m. (Mondays)
9:30-11:30 a.m. (Wednesdays)
Location: 477 Apotex Centre, A. Sehon Seminar Room


Objective:

To develop an in-depth understanding of the development, functioning and regulation of the mammalian immune system. This is the most advanced course in the Department of Immunology and is aimed at senior graduate students in immunology or those in related disciplines who wish an advanced perspective on immunologic knowledge and current research. 

Pre-requisite:
IMMU7070 - Introductory Immunology (or equivalent) or the written permission of the course Co-ordinator.  Course instructors will assume that students are familiar with immunology at the level of the Abbas textbook Basic Immunology, 2010.

Classes:
Intensive.  Lectures (2 hr/lecture) will be held twice a week (Mondays, 9:00-11:00 a.m. and Wednesdays 9:30-11:30 a.m.) in room 477, the Alec Sehon Seminar Room, in the Apotex Centre building.  At the discretion of the instructors, lectures may be didactic and/or paper-based discussions.


Evaluation:
This course will be graded based on a midterm (35% of the final mark), 1 take-home assignment (10%), participation in a formal "in class" debate on a topic to be assigned (10%) and a final exam mostly on the lectures given after the midterm (45%).  Please note that the final exam will also include about 2 questions from lectures given prior to the midterm exam.  The take-home assignment, which will be given at the end of lectures, will test students' critical thinking, analytical and synthesis abilities and will require students to design experiments (including appropriate controls) to test immunological hypotheses.  Both the mid-term and final exam questions will be of the short answer style and will test students' critical and analytical skills.

Evaluation Summary:

Midterm Exam (closed book) 35%
Final Exam (closed book) 45%
Take home assignment 10%
In-class debate 10%

Recommended Texts:

  1. Janeway, Immunobiology, 8th edition (2012)
  2. W. Paul, Fundamental Immunology, 7th edition (2012)
  3. Research papers and reviews as assigned by individual instructors (accessible via PubMed)


Class Schedule:

Jan. 13, 2014  Course Overview:  Brief review of Immunology  J. Uzonna
Jan. 15 Pattern recognition receptors and host defense peptides  N. Mookherjee
Jan. 20  Dendritic cell biology  S. Kung
Jan. 22  NK cells:  Activating and inhibitory receptors  S. Kung
Jan. 27  Haematopoesis and immunity  A. Raouf
Jan. 29  Granulocyte:  Ontogeny and function  A. Soussi Gounni
Feb. 3  Antigen Presentation, cytotoxicity and anti-viral immunity  J. Rempel
Feb. 5  Antigen receptor structure, diversity and recognition  A. Marshall
Feb. 10  B cell biology  A. Marshall
Feb. 12  Signalling through immune system receptors  A. Marshall
Feb. 17  Louis Riel Day - University Closed  
Feb. 19  Chemotaxis and homing of immune cells  F. Lin
Feb. 24  Immunologic memory  J. Uzonna
Feb. 26  Regulation of immune responses, costimulation, cytokines, Th1/Th2  K. HayGlass
Mar. 3  Cytokine and chemokine receptors:  Structure, signaling and function  A. Soussi Gounni
Mar. 5 MID-TERM EXAMINATION  
Mar. 10  Vaccines/extrinsic regulation of immune responses  X. Yang
Mar. 12  Epigenetic regulation of immune response  R. Su
Mar. 17  Transplantation  P. Nickerson
Mar. 19  Immunobiology of hemorrhagic viral infections  G. Kobinger
Mar. 24  Immunobiology HIV/AIDS  B. Ball
Mar. 26  Apotosis pathways and haematopoietic cancers  S. Gibson
Mar. 30  Tryptophan catabolism and immune regulation  K. Orihara
Apr. 2  The mucosal immune system  J. Ghia
Apr. 7  Neuroimmunology  J. Ghia
Apr. 9  Viral immunopathology and vaccines  S. Babiuk
Apr. 14  Autoimmunity and immune deficiency states  ?
Apr. 16  Immunopathology  J. Uzonna
Apr. 21  DEBATE:  Topics TBA  J. Uzonna

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