Dr. Graham Tipples
 

Medical and Scientific Director, Provincial Laboratory for Public Health (ProvLab). Alberta Health Services

Adjunct Professor, Department of Medical Microbiology and Immunology, University of Alberta
Assistant Professor, Department of Medical Microbiology, University of Manitoba

Degrees: PhD (Manitoba, 1994), FCCM, D(ABMM)

Mailing Address: University of Alberta Hospital
1B1.17 WMC
8440 - 112 Street 
Edmonton, Alberta, T6G 2J2

Tel: (780) 407-4701, Fax: (780) 407-8254
Cell: (780) 906-3895, Pager: (780) 445-6404 
E-mail: Graham.Tipples@albertahealthservices.ca

Research Interests:
Quality Assurance, diagnostics, surveillance and research on viruses causing rash illnesses in humans including measles virus, rubella virus and herpesviruses. Specific areas of interest include molecular epidemiology and viral genotyping. .

Recent Publications:
  1. Kruk T, S Ratnam, J Preiksaitis, A Lau, T Hatchette, G Horsman, P Van Caeseele, B Timmons, and G Tipples. Continuous Monitoring of the Performance of Rubella IgG and Hepatitis B Surface Antibody Assays Using Trueness Controls: Results of a Multicentre Trial. Accepted for publication in Clinical and Vaccine Immunology 2012.
  2. Wielders CC, van Binnendijk RS, Snijders BE, Tipples GA, Cremer J, Fanoy E, Dolman S, Ruijs WL, Boot HJ, de Melker HE, Hahné SJ. Mumps epidemic in orthodox religious low-vaccination communities in the Netherlands and Canada, 2007 to 2009. Euro Surveillance 2011;16(41):pii=19989. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19989  
  3. Tipples GA. Rubella diagnostic issues in Canada. J Infect Dis 204:S659-S663 (2011).
  4. Macey JF, T Tam, T Lipskie, G Tipples, T EisBrenner. Rubella Elimination, the Canadian Experience. J Infect Dis 204:S585-S592 (2011).
  5. Tipples GA, J Hiebert. Detection of measles, mumps and rubella viruses. In JR Stephenson and A Warnes (Eds.), Diagnostic Virology Protocols, 2nd edition. Springer Science and Business Media, 2011. Methods Mol Biol. 2011;665:183-93.
  6. Pellett P and GA Tipples. Human herpesviruses 6, 7 and 8. In Manual of Clinical Microbiology, 10th edition. American Society for Microbiology Press, 2011.
  7. Breuer J, C Grose, P Norberg, G Tipples, Schmid DS. A proposal for a common nomenclature for viral clades that form the species varicella-zoster virus: summary of VZV Nomenclature Meeting 2008, Barts and the London School of Medicine and Dentistry, 24-25 July 2008. J Gen Virol. 91:821-8 (2010). Epub 2010 Jan 13. Review
  8. Dallaire F, G De Serres, FW Tremblay, F Markowski, G Tipples. Long-lasting
    measles outbreak affecting several unrelated networks of unvaccinated persons. J Infect Dis 200:1602-5 (2009).
  9. Angelini P, F Kavadas, N Sharma, SE Richardson, G Tipples, C Roifman, Y Dror, Y Nofech-Mozes. Aplastic anemia following varicella vaccine. Pediatr
    Infect Dis J. 28:746-8 (2009).
  10. Bastien N, Bowness D, Burton L, Bontovics E, Winter AL, Tipples G, Minielly D, Gregg B, Cramer C, Schincariol C, Li Y. Parotitis in a child infected with triple-reassortant influenza A virus in Canada in 2007. J Clin Microbiol, 47:1896-8 (2009).
  11. Hahné, S,  J Macey, R van Binnendijk,, R Kohl, S Dolman, Y van der Veen, G Tipples, H Ruijs, T Mazzulli, A Timen, A van Loon, H de Melker. Rubella outbreak in the Netherlands, 2004-2005: high burden of congenital infection and spread to Canada. Pediatr Infect Dis J, 28:795-800 (2009).
  12. Ota K, V Kim, S Lavi, L Ford-Jones, G Tipples, R Tellier. Vaccine-strain varicella zoster virus causing recurrent herpes zoster in an immunocompetent 2-year-old. Pediatr Infect Dis J, 27:847-8 (2008).
  13. Leblanc JJ, J Pettipas, RJ Davidson, GA Tipples, J Hiebert, TF Hatchette. Detection of mumps virus RNA by real-time one-step reverse transcriptase PCR using the Light Cycler platform. J Clin Microbiol, 46:4049–4051 (2008).
  14. Hatchette T, GA Tipples, G Peters, J Zhou, Alsuwaidi, T Mailman. Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature. Pediatric Infect Dis J 27(1):75-7 (2008).
  15. Humar A, D Kumar, M Gray, G Moussa, R Kumar, B Welsh and GA Tipples. A Prospective Assessment of Cytomegalovirus Immune Evasion Gene Transcription Profiles in Transplant Patients With Cytomegalovirus Infection. Transplantation 2007;15;83:1200-6.
  16. Mubareka S,  H Richards, M Gray, GA Tipples. Evaluation of Commercial Rubella IgG Avidity Assays. J Clin Microbiol 2007;45:231-3.
  17. Pellett P and GA Tipples. Human herpesviruses 6, 7 and 8. In Manual of Clinical Microbiology, 9th edition. American Society for Microbiology Press, 2007.
  18. Tyler SD, GA Peters, C Grose, A Severini, MJ Gray, C Upton, GA Tipples. Genomic cartography of varicella-zoster virus: a complete genome based analysis of strain variability with implications for attenuation and phenotypic differences. Virology 2007;359:447-58.
  19. Peters GA, SD Tyler, C Grose, A Severini, M Gray, C Upton, GA Tipples. A full-genome phylogenetic analysis of varicella-zoster virus reveals a novel origin of replication-based genotyping scheme and evidence of recombination between major circulating clades. J Virol. 2006;80:9850-60.
  20. Rota J,  L Lowe, P Rota, W Bellini, S Redd, G Dayan, R van Binnendijk, S Hahné, G Tipples, J Macey, R Espinoza, D Posey, A Plummer, J Bateman, J Gudiño, E Cruz-Ramirez, I Lopez-Martinez, L Anaya-Lopez, TH Akwar, S Giffin, V Carrión, AM Bispo de Filippis, A Vicari, C Tan, B Wolf, K Wytovich, P Borus, F Mbugua, P Chege, J Kombich, C Akoua-Koffi, S Smit, H Bukenya, J Bwogi, FN Baliraine, J Kremer, C Muller, S Santibanez. Identification of the B3 genotype of measles virus from cases in the United States, Canada, Mexico and the Netherlands during Nov-Dec 2005 suggests a common African source of virus. Emerg Infect Dis [serial on the Internet].
    2006 Nov [date cited]. Available from http://www.cdc.gov/ncidod/EID/vol12no11/06-0635.htm
  21. Robinson JL, BE Lee, JK Preiksaitis, S Plitt and GA Tipples. Prevention of congenital rubella syndrome - what makes sense on 2006? Epidemiol Rev 2006;28:81-7.
  22. Hahné S, J Macey, G Tipples, P Varughese, A King, R van Binnendiijk, H Ruijs, J van Steenbergen, A Timen, AM van Loon and H de Melker. Rubella outbreak in an unvaccinated religious community in the Netherlands spreads to Canada. Eurosurveillance Weekly 2005;10(20):19/05/2005 (http;//www.eurosurveillance.org/ew/2005/050519.asp).
  23. Coates AL, G Tipples, K Leung, M Gray, E Louca. How many infective viral particles are necessary for successful mass measles immunization by aerosol? Vaccine 2006;24:1578-15885.
  24. Leung K, E Louca, M Gray, G Tipples, AL Coates. Use of the next generation pharmaceutical impactor for particle size distribution measurements of live viral aerosol vaccines. J Aerosol Med. 2005;18(4):414-26.
  25. Grose C, S Tyler, G Peters, J Hiebert, GW Stephens, WT Ruyechan, W Jackson, J Storlie and GA Tipples. Complete DNA sequence analyses of the first two varicella-zoster virus glycoprotein E (D150N) mutant viruses found in North America: Evolution of genotypes with an accelerated cell spread phenotype. J Virol 78:6799-807 (2004).
  26. Loparev VN, A Gonzalez, M Deleon-Carnes, GA Tipples, H Fickenscher, EG Torfason and DS Schmid. Three major genotypes of varicella-zoster virus: geographical clustering and strategies for genotyping. J Virol 78:8349-58 (2004).
  27. Tipples GA, M Garbutt, M Gray, PA Rota, and the Canadian Measles Surveillance Program. Genotyping of measles virus in Canada: 1979 to 2002.  J Infect Dis 189 (Suppl. 1):S171-S176 (2004).
  28. King A, P Varughese, G DeSerres, G Tipples, J Waters and Members of the Working Group on Measles Elimination. Measles elimination in Canada. J Inf Dis 189 (Suppl. 1):S236-S242 (2004).
  29. Tipples GA, R Hamkar T Mohktari-Azad, M Gray, G Parkyn and S Ratnam. Evaluation of rubella IgM serology assays. J Clin Virol 30:233-238 (2004).