1. Viral Infections of the Nervous System. 2. Rabies Pathogenesis. 3. Neural Apoptosis

• DETAILS OF RESEARCH INTERESTS:

Animal models and human tissues are used to study the pathogenesis of acute viral infections of the nervous system. Rabies virus infection causes a severe encephalomyelitis in mice, and this is a convenient model for studying virus-host interactions. The pathogenetic basis for the neuronal dysfunction that occurs in rabies is poorly understood. Molecular approaches are being used to examine the basis of rabies virus neurovirulence. The role of neural apoptosis is being evaluated in a variety of animal models of experimental rabies. Hopefully, these approaches will give us a better understanding of basic mechanisms involved in rabies and contribute to the development of improved therapies for viral infections.

This picture shows in situ hybridization of a rabies virus-infected ventral horn cell of the spinal cord of a mouse with grains in the cytoplasm and dendritic processes that represent rabies virus mRNA.

Recent Publications:

1. Jackson AC: Rabies. In: Tselis A, Booss, J, eds. Handbook of clinical neurology, Third Series: Neurovirology. Edinburgh; New York: Elsevier (In press).
2. Jackson AC: Rabies in the critical care unit: diagnostic and therapeutic approaches. Canadian Journal of Neurological Sciences 38(5), 2011 (In press).
3. Jackson AC: Rabies and other rhabdovirus infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison’s principles of internal medicine, 18th Edition. New York: McGraw-Hill (In press).
4. Jackson AC: Monoclonal antibody therapy and progressive multifocal leukoencephalopathy (Editorial). Canadian Journal of Neurological Sciences 38(4):545-546, 2011.
5. Jackson AC, ed. Research advances in rabies. In Advances in Virus Research series 79, 2011.
6. Jackson AC, Kammouni W, Fernyhough P: Role of oxidative stress in rabies virus infection. In: Jackson AC, ed. Research advances in rabies in Advances in Virus Research 79:127-138, 2011.
7. Jackson AC: Therapy of human rabies. In: Jackson AC, ed. Research advances in rabies in Advances in Virus Research 79:365-375, 2011.
8. Jackson AC: Update on rabies. Research and Reports in Tropical Medicine 2:31-43, 2011.
9. Jackson AC: Rabies. In: Gilman S, Johnson RT, eds. Medlink Neurology. San Diego: MedLink, 2011. Available at http://www.medlink.com
10. Jackson AC: Why does the prognosis remain so poor in human rabies? (Editorial) Expert Review of Anti-Infective Therapy 8:623-625, 2010.
11. Jackson AC, Kammouni W, Zherebitskaya E, Fernyhough P: Role of oxidative stress in rabies virus infection of adult mouse dorsal root ganglion neurons. Journal of Virology 84:4697-4705, 2009.
12. Sejvar JJ, Davis LE, Szabados E, Jackson AC: Delayed-onset and recurrent limb weakness associated with West Nile virus infection. Journal of Neurovirology 16:93-100, 2010.
13. Jackson AC, Ronald AR, Steiner I: Plagiarism (Letter). Transactions of the Royal Society of Tropical Medicine and Hygiene 104:173-174, 2010.
14. Jackson AC: Rabies pathogenesis update. Pan-Amazonian Journal of Health 1:167-172, 2010.
15. Jackson AC: Rabies. In: Bope ET, Rakel RE, Kellerman, RD, eds. Conn's Current Therapy 2010, pp 128-130. Philadelphia: Elsevier, 2010.
16. Jackson AC: Arboviral encephalitis. In: Gilman S, Johnson RT, eds. Medlink Neurology. San Diego: MedLink, 2010. Available at http://www.medlink.com
17. Jackson AC: Herpes simplex encephalitis. In: Gilman S, Johnson RT, eds. Medlink Neurology. San Diego: MedLink, 2010. Available at http://www.medlink.com
18. Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL: Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised crossover trial. The Lancet 374:1252-1261, 2009.
19. Jackson AC: Therapy of rabies encephalitis (Editorial). Biomédica 29:169-176, 2009
20. Rossiter JP, Hsu L, Jackson AC: Selective vulnerability of dorsal root ganglia neurons in experimental rabies after peripheral inoculation of CVS-11 in adult mice. Acta Neuropathologica 118:249-259, 2009
21. Jackson AC: Update on rabies diagnosis and treatment. Current Infectious Disease Reports 11:296-301, 2009.
22. Jackson AC: Update on rabies diagnosis and treatment. Current Infectious Disease Reports 11:296-301, 2009.
23. Wilde H, Hemachudha T, Jackson AC: Viewpoint: Management of human rabies. Transactions of the Royal Society of Tropical Medicine and Hygiene 102:979-982, 2008.
24. Jackson AC: Rabies. Neurologic Clinics 26:717-726, 2008.
25. Jackson AC, Scott CA, Owen J, Weli SC , Rossiter JP: Human rabies therapy: lessons learned from experimental studies in mouse models. In: Dodet B, Fooks AR, Muller T, Tordo N, eds. Towards the elimination of rabies in Eurasia. Developmental Biology (Karger, Basel ) 131:377-385, 2008.
26. Mansfield KL, Johnson N, Nunez A, Hicks D, Jackson AC, Fooks AR : Up-regulation of chemokine gene transcripts and T-cell infiltration into the central nervous system and dorsal root ganglia are characteristics of experimental European bat lyssavirus type 2 infection of mice. Journal of Neurovirology 14:218-228, 2008.
27. Guyatt GH, Cass CE, Jackson AC, Smith DH, Welch JP, Turk J: Protecting academic freedom. Open Medicine 2:e17-e19, 2008. http://www.openmedicine.ca.
28. Jackson AC, Johannsen EC: Rabies and other rhabdovirus infections. In: Fauci AS, Kasper DL, Braunwald E, Hauser SL, Longo DL, Jameson JL, Loscaizo J, eds. Harrison's principles of internal medicine, 17th Edition, pp 1222-1226. New York : McGraw-Hill, 2008.
29. Scott CA, Rossiter JP, Andrew RD, Jackson AC: Structural abnormalities in neurons are sufficient to explain the clinical disease and fatal outcome in experimental rabies in yellow fluorescent protein-expressing transgenic mice. Journal of Virology 82:513-521, 2008.
30. Taylor SW, Lee DH, Jackson AC: Herpes simplex encephalitis presenting with exclusively frontal lobe involvement. Journal of Neurovirology 13:477-481, 2007.
31. Jackson AC, Scott CA, Owen J, Weli SC, Rossiter JP: Therapy with minocycline aggravates experimental rabies in mice. Journal of Virology 81:6248-6253, 2007.
32. Jackson AC, Wunner WH, eds. Rabies, Second Edition. London: Elsevier Academic Press, 2007.
33. Jackson AC: Human disease. In: Jackson AC, Wunner WH, eds. Rabies, Second Edition. pp 309-340. London: Elsevier Academic Press, 2007.
34. Jackson AC: Pathogenesis. In: Jackson AC, Wunner WH, eds. Rabies, Second Edition. pp 341-381. London: Elsevier Academic Press, 2007.
35. Rossiter JP, Jackson AC: Pathology. In: Jackson AC, Wunner WH, eds. Rabies, Second Edition. pp 383-409. London: Elsevier Academic Press, 2007.
36. Jackson AC: Future developments and challenges. In: Jackson AC, Wunner WH, eds. Rabies, Second Edition. pp 635-643. London: Elsevier Academic Press, 2007.  
37. Jackson AC: Rabies. In: Rakel RE, Bope ET, eds. Conn's Current Therapy 2007, pp 147-149. Philadelphia: Elsevier, 2007.
38. Hemachudha T, Sunsaneewitayakul B, Desudchit T, Suankratay C, Sittipunt C, Wacharapluesadee S, Khawplod P, Wilde H, Jackson AC: Failure of therapeutic coma and ketamine for therapy of human rabies. Journal of Neurovirology 12:407-409, 2006.
39. Weli SC, Scott CA, Ward CA, Jackson AC: Rabies virus infection of primary neuronal cultures and adult mice: failure to demonstrate evidence of excitotoxicity. Journal of Virology 80:10270-10273, 2006.
40. Jackson AC, Rossiter JP, Lafon M: Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases. Journal of Neurovirology 12:229-234, 2006.
41. Jackson AC: Bat rabies virus variants causing human rabies (Letter). Pediatric Infectious Disease Journal 25:570, 2006.
42. Jackson AC: Rabies: new insights into pathogenesis and treatment. Current Opinion in Neurology 19:267-270, 2006.      
    

RABIES LINKS
[ Kansas State University ]  [ Centers for Disease Control (USA) ]
[ World Health Organization ]