Dr. Sandra Kiazyk
 
Adjunct Professor, Department of Medical Microbiology, University of Manitoba. Research Scientist, National Reference Centre for Mycobacteriology/ National Laboratory for HIV Immunology, National Microbiology Laboratory,Public Health Agency of Canada

Degrees: Ph.D. (Medical Microbiology, University of Manitoba, 2007). BSc.(H) Microbiology, University of Manitoba

Mailing Address: National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, MB. R3E 3P6

Tel: (204) 784-7532, Fax: (204) 789-2018
E-mail:sandra.kiazyk@phac-aspc.gc.ca

Research Interests:
Dr. Kiazyk directs a new program in the area of Tuberculosis (TB) infection and immunology, bridging both the National Reference Centre for Mycobacteriology, and the National Laboratory for HIV Immunology. We utilize cutting edge immunology techniques such as multiparametric flow cytometry and multiplex cytokine analysis to understand TB-specific immune responses. The program is curently focused on studies relating to improved TB immunodiagnostics, correlates of TB immunity, immunopathogenesis of TB in the context of type 2 diabetes, and TB/HIV coinfection

Recent Publications:

  1. Jennifer Juno, Jeffrey Tuff, Robert Choi, Catherine Card, Joshua Kimani, Charles Wachihi, Sandra Kiazyk, T. Blake Ball, Carey Farquhar, Francis A Plummer, Grace John-Stewart, Ma Luo and Keith R Fowke.  The Role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 Acquisition, Progression and Immune Activation. Retrovirology 2012, 9:1
  2. Michael O. Eze*, Sandra Kiazyk*, Carole M. Beaudoin, Lisa Lin, Francis A. Plummer, Anton Andronov, and Keith R. Fowke,   GB virus C in HIV co-infected individuals: Could there ever be a consensus on outcome?  Accepted for Publication in Current Trends in Microbiology (Dec 2011)   (*denotes equal contributors)
  3. Luo M, Daniuk CA, Diallo TO, Capina RE, Kimani J, Wachihi C, Kimani M,   Bielawny T, Peterson T, Mendoza MG, Kiazyk S, Ball TB, Plummer FA. For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection. Journal of Virology. 2012 Jan;86(2):1166-80. Epub 2011 Nov 9.
  4. Meika Richmond, Lyle R. McKinnon, Sandra A. Kiazyk, Charles Wachihi, Makobu Kimani, Joshua Kimani, Francis A. Plummer, T. Blake Ball. Epitope mapping of HIV-specific CD8+ T cell responses by multiple immunological readouts reveals distinct specificities defined by function. Journal of  Virology. 2011, 85(3):1275-86. Epub 2010 Nov 17.
  5. McKinnon, L. R., R. Capina, H. Peters, M. Mendoza, J. Kimani, C. Wachihi, A. Kariri, M. Kimani, M. Richmond, S. K. Kiazyk, K. R. Fowke, W. Jaoko, M. Luo, T. B. Ball, and F. A. Plummer. Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24. Journal of Virology.2009, 83:12636-42.
  6. Sandra K. Kiazyk, Keith R. Fowke. Loss of CD127 expression links immune activation and CD4+ T cell loss in HIV infection. Trends in Microbiology (invited). 2008, Dec; 16(12):567-73.
  7. Sandra A. Koesters, Charles Wachichi, Lucy Matu, Joshua Kimani, Joanne Embree,Francis A. Plummer, and Keith R. Fowke. IL-7Ra expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Journal of European Immunology. 2006, Feb; 36(2):336-44.