Dr. Binhua Liang
 
Head, Viral Bioinformatics, National Microbiology Laboratory-Public Health Agency of Canada
Adjunct Professor, Departments of Medical Microbiology, University of Manitoba
Visiting Professor, Centre for Bioinformatics and biotechnology, University of Nairobi, Kenya

Degrees:M.D. (Changchun, 1989), M.Sc. (Manitoba, 1999), Ph.D. (Manitoba, 2010)

Mailing Address:National Microbiology Laboratory-Public Health Agency of Canada,
1015 Arlington Street, Winnipeg, MB R3E 3R2

Tel: (204)789-2039
E-mail:ben.liang@phac-aspc.gc.ca; or liangb0@cc.umanitoba.ca

Research Interests:
Application of next-generation sequencing (NGS) technologies in HIV, HCV, and Influenza research; Development of viral Bioinformatics approaches/or software in sequence analysis, database, Web applications, and graphical user interfaces; HIV Genetics, Evolution, and molecular epidemiology; HIV Drug Resistance research; Development of methodologies and platforms for Microarray and RNA-Seq data analysis

Publications:

  1. Ji H, Li Y, Liang B, Pilon R, MacPherson P, Bergeron M, etc. Pyrosequencing dried blood spots reveals differences in HIV drug resistance between treatment naïve and experienced patients. PLoS One. 2013;8(2):e56170.
  2. Peterson TA, Kimani J, Wachihi C, Bielawny T, Kariri T, Liang B, Ball TB, Plummer FA, and Luo M. Tissue Antigens. 2013 Feb;81(2):93-107.
  3. Ji H, Liang B, Li Y, Van Domselaar G, Graham M, Tyler S, Merks H, Sandstrom P, and Brooks J. J Viro Methods. 2013 Feb;187(2):314-20.
  4. Songok EM, Luo M, Liang B, Mclaren P, Kaefer N, etc. Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state. PLoS One. 2012;7(1):e30048.
  5. Liang B, Luo M, Scott-Herridge J, Semeniuk C, Mendoza M, Capina R, MacArther I, Sheardown B, Ball TB, Domselaar GV, Jones SJ, and Plummer FA. A comparison of 454 Pyrosequencing and Sanger Cloning sequencing methods in charactering genetic diversity of HIV-1 genes and its impact on the functions of HIV-1 genes. PLoS One. 2011; 6(10):e26745
  6. Ji H, Li Y, Graham M, Liang B, Pilon R, Tyson S, Peters G, Tyler S, Marks H, Bertagnolio S, Soto Ramirez L, Sandstrom P, and Brooks J. Pooled pyrosequencing of dried blood spot specimens is an efficient and cost-effective method of conducting HIV drug resistance threshold surveys. Antiviral Therapy. 2011; 16(6):871-8
  7. Graham M, Liang B, Van Domselaar G, Bastien N, Beaudoin C, Tyler S, Kaplen B, Landry E, the National Influenza A/H1N1 pdm Genomics Study Team (NIGST), and Li Y. Nationwide Molecular Surveillance of Pandemic H1N1 Influenza A Virus Genomes: Canada, 2009. PLoS One. 2011 Jan 7; 6(1):e16087.
  8. Cuff WR, Duvvuri VR, Liang B, Duvvuri B, Wu GE, Wu J and Tsang RS. A novel interpretation of structural dot plots of genomes derived from the analysis of two strains of Neisseria meningitides. Genomics Proteomics Bioinformatics. 2010 Sep; 8(3):159-69
  9. Liang B, Luo M, Ball B, Jones S, and Plummer F. QUASI Analysis of Host Immune Responses to Gag Polyproteins of Human Immunodeficiency Virus Type I by A Systematic Bioinformatics Approach. Biochem Cell Biol. 2010 Aug; 88(4):671-81.
  10. Ji H, Masse N, Tyler S, Liang B, Li Y, Merks H, Graham M, Sanstrom P, Brooks J. HIV drug resistance surveillance using pooled pyrosequencing. PloS One. 2010 Feb 17; 5(2): e9263
  11. Cuff WR, Liang B, Duvvur VR, and Wu JH. Characteristics of outbreak-responses: Canadian SARS example. 18th World IMACS/MODSIM Congress. Modelling and Simulation Society of Australia and New Zealand and International Association for Mathematics and Computer in Simulation. 2009 July: 2377-83
  12. McKinnon LR, Mao X, Kimani J, Wachihi C, Semeniuk C, Mendoza M, Liang B, Luo M, Fowke KR, Plummer FA, Ball TB. Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection. PLos One. 2009 Sep 11; 4(9):e6965
  13. Liang B, Luo M, Ball B, Jones S, Yao X, Domslelaar GV, Cheang M, and Plummer F. Systematic Analysis of Host Immunological Pressure on the Envelope Gene of Human Immunodeficiency Virus Type 1 by an Immunological Bioinformatics Approach. Current HIV Research. 2008 Jun; 6(4):370-9
  14. Ji H, Ball TB, Liang B, Kimani J, and Plummer FA. Human interferon regulatory factor-1 gene and its promoter sequences revealed by population-based complete gene sequencing. DNA Seq. 2008 Jun; 19(3): 326-31
  15. Liang B, Luo M, Ball B, and Plummer F. QUASI Analysis of the HIV-1 Envelope Sequences in Los Alamos National Laboratory HIV Sequence Database: Pattern and Distribution of PS Sites and their Frequencies over Years. Biochem Cell Biol. 2007 Apr; 85(2):259-264
  16. Liu KZ, Man A, Shaw R.A, Liang B, Xu ZL, and Gong YW. Molecular determination of liver fibrosis by synchrotron infrared microspectroscopy. Biochimica et Biophysica Acta. 2006 Jul; 1758(7): 960-967

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