Dr. Michael Mulvey
 

Associate Professor, Department of Medical Microbiology, University of Manitoba. 
Adjunct Professor, Department of Microbiology, University of Manitoba. 
Adjunct Professor, Department of Medical Microbiology, University of Calgary. 
Chief, Antimicrobial Resistance and Nosocomial Infections, National Microbiology Laboratory, Public Health Agency of Canada

Degrees:  PhD ( Manitoba , 1990) Academic Research Microbiologist, Canadian College of Microbiologists

Mailing Address: National Microbiology Laboratory, 1015 Arlington St .Winnipeg, Manitoba, R3E 3R2

Tel: (204) 789-2133, Fax: (204) 789-2018
E-mail: Michael.Mulvey@phac-aspc.gc.ca
Research Interests:
Antimicrobial resistance and usage surveillance, molecular mechanisms and epidemiology of antimicrobial resistant organisms, linkages between virulence and resistance.

Additional activities related to Dr. Mulvey's position as Chief of Antimicrobial Resistance and Nosocomial Infections at the National Microbiology Laboratory can be found at http://www.nml-lnm.ca/english/entericsARN_e.htm.  

Recent Publications:

  1. Golding, G. R., P. N. Levett, R. N. McDonald, J. Irvine, B. Quinn, M. Nsungu, S. Woods, M. Khan, M. Ofner-Agostini, M. R. Mulvey, and the Northern Antibiotic Resistance Partnership. USA400 Causing High Rates of Infection in Remote Communities of Norther Canada.  Emerging Infectious Diseases 2011; In press.
  2. MacDonald, T., J. M. Langley, T. Mailman, K. Allain, G. Nelson, L. Hatton, T. Sanford, K. George, D. Hancock, D. Stinson, M. Mulvey.  Serratia marcescens outbreak in an NICU related to the exit port of an oscillator. Pediatric Critical Care Medicine 2011; In press.
  3. Mulvey M. R., M. Doupe, M. Prout, C. Leong, R. Hizon, A. Grossberndt, M. Klowak,  A. Gupta, M. Melanson, A. Gomori, F. Esfahani, L. Klassen, E. E. Frost, and M. Namaka. Staphylococcus aureus Harbouring Enterotoxin A as a Possible Risk Factor for Multiple Sclerosis Exacerbations. Multiple Sclerosis 2011; In press.
  4. Mulvey, M. R., J. M. Grant, K. Plewes, D. Roscoe, DA. Boyd. New Delhi Metallo-Beta-Lactamase in Klebsiella pneumoniae and Escherichia coli, Canada. Emerging Infectious Diseases 2011; 1:103-106.
  5. Kim, J., C. Ferratro, G. R. Golding, M. R. Mulvey, K. A. Simmonds, L. W. Svenson, G. Keays, L. Chui, M. Lovgren, and M. Louie.  Changing epidemiology of methicillin-resistant Staphylococcus aureus in Alberta, Canada: population-based surveillance 2005-2008. Epidemiology and Infection 2010; 21:1-10
  6. Floras, A., K. Lawn, D. Slavic, M. R. Mulvey, G. R. Golding, J. Scott Weese. Sequence type 398 methicillin-resistant Staphylococcus aureus infection and colonization in dogs. Veterinary Record 2010; 166:826-7.
  7. Simor, A. E., L. Louie, C. Watt, D. Gravel, M. Mulvey, J. Campbell, A. McGeer, E. Bryce, M. Loeb, A. Matlow, and the Canadian Nosocomial Infection Surveillance Program. Antimicrobial Susceptibilities of Healthcare-Associated and Community-Associated Strains of Methicillin-Resistant Stapylococcus aureus (MRSA) from Hospitalized Patients in Canada, 1995-2008. 2010. Antimicrobial Agents and Chemotherapy 2010; 54:2265-8.
  8. Mataseje, L. F., P. J. Baudry, G. G. Zhanel, D. W. Morck, R. R. Read, M. Louie, M. Mulvey. Comparison of CMY-2 plasmids Isolated from Human, Animal and Environmental Escherichai coli and Salmonella ssp. From Canada. Diagnostic Microbiology and Infectious Disease 2010; 67:387-91.
  9. Cordeiro, R. P., T. Du, M. R. Mulvey, D. O. Krause and R.A. Holley. Susceptibility of meat starter cultures to antimicrobials used in food animals in Canada. Journal of Food Protection 2010; 73:916-22.
  10. Golding, G. R., L. Bryden, P. N. Levett, R. R. McDonald, A. Wong, J. Wylie, M. R. Graham, S. Tyler, G. Van Domselaar, A. E. Simor, D. Gravel, and M. R. Mulvey. Livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 in humans, Canada. Emerging Infectious Diseases 2010; 16:587-94.
  11. Mulvey, M., D. Boyd, D. Gravel, J. Hutchinson, S. Kelly, A. McGeer, D. Moore, A. E. Simor, K. N. Suh, G. Taylor, J. C. Weese, M. Miller, and the Canadian Nosocomial Infection Surveillance Program. Hypervirulent Clostridium difficile in hospitalized patients, Canada. Emerging Infectious Diseases 2010; 16:678-81.
  12. Zhanel, G. G., M. DeCorby, H. Adam, P. Lagacé-Wiens, K. A. Nichol, A. Wierzbowski, P. J. Baudry, F. Tailor, J. A. Karlowsky, A. Walkty, F. Schweizer, M. McCracken, M. R. Mulvey, J. Johnson,  The Canadian Antimicrobial Resistance Alliance (CARA) and D. J. Hoban.  Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2008). Antimicrobial Agents and Chemotherapy 2010; 54: 4684-4693.
  13. Said, K. B., J. Ishmail, J. Campbell, M. R. Mulvey, A. M. Bourgault, S. Mercier, and X. Zhae. Regional profiling for genotype diversity of mastitis-specific Staphylococcus aureus lineage in Canada using clumping factor A, pulsed field gel electrophoresis, and spa-typing. Journal of Clinical Microbiology 2010; 48:375-86.
  14. Walkty, A., D. Boyd, D. Gravel, J. Hutchinson, A. McGeer, D. Moore, A. Simor, K. Suh, G. Taylor, M. Miller, M. R. Mulvey, and the Canadian Nosocomial Infection Surveillance Porgram. Molecular Characterization of Moxifloxacin Resistance from Canadian Clostridium difficile Clinal Isolates. Diagnostic Microbiology and Infectious Disease 2010; 66:419-24.
  15. Quesada-Gómez, C., C. Rodriguez, M. del Mar Gamboa-Coronado, E. Rodriguez-Cavallini, T. Du, M. R. Mulvey, M. Villalobos-Zúñiga, R. Boza-Cordero. The emergence of Clostridium difficile NAP1 in Latin America. Journal of Clinical Microbiology 2010; 48:669-70.
  16. Golding, G. R., P. N. Levett, R. R. McDonald, J. Irvine, M. Nsungu, S. Woods, A. Horbal, C.G. Siemens, M. Khan, M. Ofner-Agostini, M. R. Mulvey, and the Northern Antibiotic Resistance Partnership (NARP). A comparison of risk factors associated with community-associated methicillin-resistant and –susceptible Staphylococccus aureus infections in Northern communities in Canada. Epidemiology and Infection 2010; 22:1-8.
  17. Adam, H. J., L. Louie, C. Watt, D. Gravel, E. Bryce, M. Loeb, A. Matlow, A. McGeer, M. R. Mulvey, A. E. Simor, and the Canadian Nosocomial Infection Surveillance Program. Detection and Characterization of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus (hVISA) in Canada: Results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006. Antimicrobial Agents and Chemotherapy 2010; 54:945-9.
  18. Baudry, P. J., L. Mataseje, G. G. Zhanel, D. J. Hoban, M. R. Mulvey. Characterization of plasmids encodingCMY-2 AmpC ß-lactamases from Escherichia coli in Canadian Intensive care units. Diagnostic Microbiology and Infectious Disease 2009; 65:379-83.
  19. Simor, A. E., N. Gilbert, D. Gravel, M. R. Mulvey, E. Bryce, M. Loeb, A. Matlow, A. McGeer, L. Louie, J. Campbell, and the Canadian Nosocomial Infection Surveillance Program. Methicillin-Resistant Staphylococcus aureus in Canada: National Surveillance and Changing Epidemiology, 1995-2007. Infection Control and Hospital Epidemiology 2010; 31:348-56.
  20. Miller, M., D. Gravel, M. Mulvey, G. Taylor, D. Boyd, A. Simor, M. Gardam, A. McGeer, J. Hutchinson, D. Moore, S. Kelly, and the Canadian Nosocomial Infection Surveillance Program (CNISP). Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clinical Infectious Diseases 2010; 50:194-201.
  21. Boyd, D. A., and M. R. Mulvey. TEM-168, a heretofore laboratory-derived TEM β-lactamase variant found in an Escherichia coli clinical isolate. Antimicrobial Agents and Chemotherapy 2009; 53:4955-6.
  22.  Mataseje, L. F., J. Xiao, S. Kost, L-K. Ng, K. Dore, M. R. Mulvey, and the Canadian Public Health Laboratory Network. Characterization of Canadian cefoxitin-resistant non-typhoidal Salmonella isolates, 2005-2006. Journal of Antimicrobial Chemotherapy 2009; 64:723-7:30.
  23. Ofner-Agostini, M., A. Simor, M. Mulvey, A. McGeer, Z. Hirji, M. McCracken, D. Gravel, D. Boyd, and the Canadian Nosocomial Infection Surveillance Program (CNISP) and E. Bryce. Risk Factors for and Outcomes Associated with Clinical Isolates of Escherichia coli and Klebsiella spp. Resistant to Extended-Spectrum Cephalosporins. Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:e43-e48.
  24. McCracken, M., M. DeCorby, J. Fuller, V. Loo, D. Hoban, G. G. Zhanel, M. Mulvey. Identification of Multi-Drug and Carbapenem-Resistant Acinetobacter baumannii in Canada: Results from CANWARD 2007. Journal of Antimicrobial Chemotherapy 2009; 64:552-5.
  25. Wong, H., L. Louie, C. Watt, E. Sy, R.Y.C. Lo, M. R. Mulvey, the Canadian Noscomial Infection Surveillance Program, and A.E. Simor. Characterization of ermA in Macrolide-Susceptible Strains of Methicillin-Resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2009; 53:3602-3.
  26. Clermont O., H. Dhanji, M. Upton, T. Gilbreel, A. Fox, D. Boyd, M.R. Mulvey, P. Nordmann, E. Rupp, J.L. Sarthou, T. Frank, S. Vimont, G. Arlet, C. Branger, N. Woodford, E. Denamur. Rapid detection of the O25b-ST131clone of Escherichia coli encompassing the CTX-M-15 producing strains. Journal of Antimicrobial Chemotherapy 2009; 64:274-7.
  27. Murray, R., D. Boyd, P. Levett, M. R. Mulvey, and M. J. Alfa. Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A. BMC Infectious Diseases 2009; 9:103-113.  
  28. Mataseje, L. F., N. Neuman, B. Crago, P. Baudry, G. G. Zhanel, M. Louie, M. R. Mulvey, and the ARO Water Study Group. Characterization of cefoxitin-resistant Escherichia coli isolated from recreational beaches and private drinking water in Canada between 2004 and 2006. Antimicrobial Agents and Chemotherapy 2009; 53:3126-30.
  29. Zhanel, G. G., J. A. Karlowsky, M. DeCorby, K. A. Nichol, A. Wierzbowski, P. J. Baudry, P. Lagace-Wiens, A. Walkty, F. Schweizer, M. McCracken, M. R. Mulvey, The Canadian Antimicrobial Resistance Alliance (CARA) and D.J. Hoban. Prevalence of antimicrobial resistant pathogens in Canadian hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007). Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:Suppliment A, 9A-19A.
  30. Zhanel, G. G., M. DeCorby, K. A. Nichol, A. Wierzbowski, P. J. Baudry, F. Tailor, P. Lagace-Wiens, A. Walkty, S. Fanella, O. Larios, M. R. Mulvey, M. McCracken, J. A. Karlowsky, The Canadian Antimicrobial Resistance Alliance (CARA) and D. J. Hoban. Antimicrobial susceptibility of 6,685 isolated from Canadian hospitals: CANWARD 2007. Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:Suppliment A, 20A-30A. 
  31. Nichol, K. A., M. DeCorby, K. Thompson, M. McCracken, M. R. Mulvey, J. A. Karlowsky, D. J. Hoban and G. G. Zhanel. Comparison of community-associated and hospital-associated methicillin resistant Staphylococcus aureus in Canada: Results from CANWARD 2007. Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:Suppliment A, 31A-36A.
  32. Baudry, P. J., M. McCracken, P. R. S. Lagace-Wiens, M. R. Mulvey, G.G. Zhanel and D.J. Hoban. Prevalence and characterization of extended-spectrum ß -lactamase producing Enterobacteriaceae isolated in Canadian hospitals: Results from CANWARD 2007. Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:Suppliment A, 43A-48A.
  33. Walkty, A., M. DeCorby, K. A. Nichol, M. McCracken, M. R. Mulvey, J. A. Karlowsky, D. J. Hoban and G. G. Zhanel. Characterization of Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: Results of the CANWARD study 2007. Canadian Journal of Infectious Diseases and Medical Microbiology 2009; 20:Suppliment A, 54A-58A.
  34. Antoniou, T., R. Devlin, K. Gough, M. Mulvey, K. C. Katz, M. Zehtabchi, J. Polsky, D. Tilley, J. Brunetta, G. Arbess, C. Guiang, B. Chang, C. Kovacs, A. Ghavam-Rassoul, C. Cavacuiti, B. Corneslon, P. Berger, M. R. Loutfy. Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men. Int J STD AIDS 2009; 20:180-3. 
  35. Gravel, D., M. Miller, A. Simor, G. Taylor, M. Gardam, A. McGeer, J. Hutchinson, D. Moore, S. Kelly, D. Boyd, M. Mulvey, and the Canadian Nosocomial Infection Surveillance Program. Healthcare-Associated Clostridium difficile Infection in Adults admitted to Acute-Care Hospitals in Canada: A Canadian Nosocomial Infection Surveillance Program Study. Clinical Infectious Diseases 2009; 48:568-576.
  36. Baudry, P. J., K. Nichol, M. DeCorby, P. Lagacé-Wiens, E. Olivier, D. Boyd, M. R. Mulvey, D. J. Hoban, G. G. Zhanel. Mechanisms of resistance and mobility among multidrug-resistant CTX-M-producing Escherichia coli from Canadian intensive care units: the 1st report of QepA in North America. Diagn Microbiol Infect Dis 2009; 63:319-26.
  37. Gravel, D., M. Gardam, G. Taylor, M. Miller, A. Simor, A. McGeer, J. Hutchinson, D. Moore, S. Kelly, M. Mulvey, and the Canadian Nosocomial Infection Surveillance Program. Infection Control Practices related to Clostridium difficile infection within acute-care hospitals in Canada. American Journal of Infection Control 2009; 37:9-14.
  38. Mulvey, M. R., E. Susky, M. McCracken, D. W. Morck and R. R. Read. Similar cefoxitin resistance plasmids circulating in Escherichia coli from human and animal sources. Veterinary Microbiology 2009; 134:279-87.
  39. Martin, H., L. P. Abbott, D. E. Low, M. Mulvey, and J. S. Weese. Genotypic investigation of Clostridium difficile in Prince Edward Island. The Canadian Journal of Infectious Diseases and Medical Microbiology 2008; 19:409-412.
  40. Isabel S., E. Leblanc, M. Boissinot, D. K. Boudreau, M. Grondin, F. J. Picard, E. A. Martel, N. J. Parham, P. S. G. Chain, D. E. Bader, M. R. Mulvey, L. Bryden, P. H. Roy, M. Ouellette, and M. G. Bergeron. Divergence Among Genes Encoding the Elongation Factor Tu of Yersinia Species. Journal of Bacteriology 2008; 190:7548-7558.
  41. Zhanel, G. G., M. DeCorby, K. A. Nichol, A. Wierzbowski, P. J. Baudry, J. A. Karlowsky, P. Lagacé-Wiens, A. Walkty, M. R. Mulvey, D. J. Hoban, The Canadian Antimicrobial Resistance Alliance (CARA). Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006. Diagn Microbiol Infect Dis 2008; 62:67-80.
  42. Sharma, R., K. Munns, T. Alexander, T. Entz, P. Mirzaagha, L. J. Yanke, M. R. Mulvey, E. Topp and T. McAllister. Diversity and Distribution of Commensal Fecal Escherichia coli in Beef Cattle Administered Selected Subtherapeutic Antimicrobials in a Feedlot Setting. Applied and Environmental Microbiology 2008; 74:6178-6186.
  43. Golding, G. R., J. Campbell, D. J. Spreitzer, J. Veyhl, K. Surynicz, A. Simor, M. R. Mulvey and the Canadian Nosocomial Infection Surveillance Program. A Preliminary Guideline for the Assignment of Methicillin-Resistant Staphylococcus aureus to a Canadian Pulsed-Field Gel Electrophoresis Epidemic Type using spa Typing.  The Canadian Journal of Infectious Diseases and Medical Microbiology 2008; 19:273-281.
  44. Martin, H., B. Willey, D. E. Low, H. R. Staempfli, A. McGeer, P. Boerlin, M. Mulvey, J. S. Weese. Characterization of Clostridium difficile isolated from patients in Ontario, Canada from 2004 to 2006. J Clin Microbiol 2008; 46:2999-3004.
  45. Boyd, D. A., B.M. Willey, D. Fawcett, N. Gillani, and M. R. Mulvey.Molecular Characterization of Enterococcus faecalis N06-0364 with Low-Level Vancomycin Resistance Harboring a Novel D-Ala-D-Ser Gene Cluster, vanL. Antimicrobial Agents and Chemotherapy 2008; 52:2667-72.
  46. Doublet, B., G. R. Golding, M. R. Mulvey, A. Cloeckaert. Secondary Chromosomal Attachment Site and Tandem Integration of the Mobilizable Salmonella Genomic Island 1. PLoS One 2008; e2060.
  47. Walkty, A., M. DeCorby, K. Nichol, M. R. Mulvey, D. Hoban, G. Zhanel. Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian intensive care units as part of the Canadian National Intensive Care Unit study. Diagnostic Microbiology and Infectious Disease 2008; 61:217-21.
  48. Zhanel, G. G., M. DeCorby, N. Laing, B. Weshoweski, R. Vashisht, F. Tailor, K. Nichol, A. Wierzbowski, T. Baudry, J.A.M. Karlowsky, P. Lagace-Wiens, A. Walkty, M. McCracken, M. Mulvey, J. Johnson, The Canadian Antimicrobial Resistance Alliance (CARA) and D. J. Hoban. Antimicrobial resistant pathogens in intensive care units across Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005/2006. Antimicrobial Agents and Chemotherapy 2008; 52:1430-7.
  49. Zhanel, G. G., M. DeCorby, K. Nichol, T. Baudry, J.A. Karlowsky, P. Lagace-Wiens, M. McCracken, A. Walkty, M. Mulvey, J. Johnson, The Canadian Antimicrobial Resistance Alliance (CARA) and D.J. Hoban. Characterization of MRSA VRE and ESBL producing E. coli in intensive care units across Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005/2006. Canadian Journal of Infectious Diseases and Medical Microbiology 2008; 19:243-249. 
  50. Baudry, P. J., K. Nichol, M. DeCorby, M. R. Mulvey, D. J. Hoban and G. G. Zhanel. Comparison of Antimicrobial Resistance Profiles Among Extended-Spectrum ß -Lactamase Producing- and Acquired AmpC ß -Lactamase Producing Escherichia coli from Canadian Intensive Care Units. Antimicrobial Agents and Chemotherapy 2008; 52:1846-9. 
  51. Ofner-Agostini, M., B. L. Johnston, A. E. Simor, J. Embil, A. Matlow, M. Mulvey, D. Ormiston, Canadian Nosocomial Infection Surveillance Program, and J. Conly. Vancomycin- resistant enterococci (VRE) in Canada: Results from the Canadian Nosocomial Infection Surveillance Program (CNISP) 1999-2005. Infection Control and Hospital Epidemiology 2008; 29:271-4.
  52. Dalloo, A., I. Sobol, C. Palacios, M. Mulvey, D. Gravel, and L. Panaro. Investigation of community-associated methicillin-resistant Staphylococcus aureus in a remote northern community, Nunavut, Canada. Can Comm Dis Report 2008; 34:1-7.
  53. Boyd, D. A., X. Shi, Q-H Hu, L.-K. Ng, B. Doublet, A. Cloeckaert, and M. R. Mulvey. Salmonella Genomic Island 1 (SGI1), Variant SGI1-I, and a New Variant SGI1-O in Proteus mirabilis Clinical and Food Isolates from China. Antimicrobial Agents and Chemotherapy. Antimicrobial Agents and Chemotherapy 2008; 52:340-4.
  54. Amiali, N. M., M. R. Mulvey, B. Berger-Bächi, J. Sedman, A. E. Simor, A. A. Ismail. Evaluation of Fourier transform infrared spectroscopy for the rapid identification of glycopeptide-intermediate Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 2008; 61:95-102.