Current Topics:

• What is the role of kidneys in blood pressure regulation and hypertension?
• What is the role of brain centres in blood pressure regulation?
• What is the role of lipids in normal heart function and atherosclerosis?
• How do blood clotting mechanisms change in diabetes and other disorders?
• What is the role of nitric oxide in pediatric hypertension?
• What are the mechanisms of reperfusion injury in heart following ischemia?
• How does conjugated linoleic acid and other functional foods affect heart function and disease?
• What are the gene products that cause programmed cell death in heart tissue?

Faculty Involved:

Representative Publications (last 4 years):

2010

Behbahani J, Thandapilly SJ, Louis XL, Huang Y, Shao Z, Kopilas MA, Wojciechowski P, Netticadan T, Anderson HD.  Effects of resveratrol on small artery compliance and remodeling in the spontaneously hypertensive rat.   Am J Hypertens. 2010 Jul 29. [Epub ahead of print].  [Impact factor 3.122]

Hunt WT, Kamboj A, Anderson HD, Anderson CM.  Protection of cortical neurons from excitotoxcity by conjugated linoleic acid. J Neurochem. 2010 Jul 13. [Epub ahead of print]  [Impact factor 4.500]

Thandapilly SJ, Wojciechowski P, Behbahani J, Louis XL, Yu L, Juric D, Kopilas MA, Anderson HD, Netticadan T.  Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure.  Am J Hypertens. 2010; 23:192-196.  [Impact factor 3.122]

2009

2007
Van Q, Liu J, Lu B, Feingold KR, Shi Y, Lee RM, Hatch GM.  Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells. Biochem J. 2007;401(1):103-9. 

Mink SN, Kasian K, Jacobs J, Cheng ZQ,  Light RB.  N,N’ – diacetylchitobiose, an inhibitor of lysozyme, reverses myocardial depression and lessens norepinephrine requirements in Escherichia coli sepsis in dogs.  Shock 29: 681-687, 2008 ( 2007 Sep 20; [Epub ahead of print]

Mink SN, Zhao-Qin Cheng, Bose R, Jacobs H, Kasian K, Roberts DE, Light RB.  Lysozyme, a mediator of sepsis, impairs cardiac adrenergic response by non-endothelial release of nitric oxide and inhibitory G protein signaling.  Am J Physiol  Heart Circ Physiol 293: 3140-3149, 2007.

2006

Buduhan G, Tan, Kasian K, Mink SN.  Volume reduction surgery impairs immediate post-operative pulmonary function in canine emphysema.  Am J Respir Crit Care Med 174:1310-1318, 2006.

Forte P, Ogborn MR, Lilley-Chan T.  A noninvasive, sensitive, specific, and reliable approach to assess whole-body nitric oxide synthesis in children. Pediatr Res. 2006;59(5):736-41.

McNicol A, Zhu R, Pesun R, Pampolina C, Jackson EC, Bowden GH, Zelinski T.  A role for immunoglobulin G in donor-specific Streptococcus sanguis-induced platelet aggregation. Thromb Haemost. 2006;95(2):288-93.

Robertson C, Booth SA, Beniac DR, Coulthart MB, Booth TF, McNicol A.  Cellular prion protein is released on exosomes from activated platelets. Blood. 2006;107(10):3907-11.

Shaw J, Zhang T, Rzeszutek M, Yurkova N, Baetz D, Davie JR, Kirshenbaum LA.  Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes. Circ Res. 2006;99(12):1347-54

2005
Baetz D, Shaw J, Kirshenbaum LA.  Nuclear factor-kappaB decoys suppress endotoxin-induced lung injury. Mol Pharmacol. 2005;67(4):977-9.

Baetz D, Regula KM, Ens K, Shaw J, Kothari S, Yurkova N, Kirshenbaum LA.  Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation. 2005;112(24):3777-85.

Jacobs H, Mink SN, Duke K, Bose D, Cheng ZQ, Howlett S, Ferrier GR, Light RB.  Characterization of membrane N-glycan binding sites of lysozyme for cardiac depression in sepsis. Intensive Care Med. 2005;31(1):129-37.

Lu B, Jiang YJ, Zhou Y, Xu FY, Hatch GM, Choy PC.  Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Biochem J. 2005;385(Pt 2):469-77.

Mink SN, Bose R, Roberts DE, Jacobs H, Duke K, Bose D, Cheng ZQ, Light RB.  Lysozyme binding to endocardial endothelium mediates myocardial depression by the nitric oxide guanosine 3',5' monophosphate pathway in sepsis. J Mol Cell Cardiol. 2005;39(4):615-25.

Pampolina C, McNicol A.  Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. Thromb Haemost. 2005;93(5):932-9.

2004
Aminot-Gilchrist DV, Anderson HD.  Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid. Am J Clin Nutr. 2004;79(6 Suppl):1159S-1163S.

Anderson HD, Wang F, Gardner DG.  Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004;279(10):9287-97.

Anderson HD, Rahmutula D, Gardner DG.  Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004;279(2):963-9.

Hatch GM.  Cell biology of cardiac mitochondrial phospholipids. Biochem Cell Biol. 2004;82(1):99-112.

Jiang YJ, Lu B, Xu FY, Gartshore J, Taylor WA, Halayko AJ, Gonzalez FJ, Takasaki J, Choy PC, Hatch GM.  Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. J Lipid Res. 2004;45(2):244-52.

Mink SN, Jacobs H, Duke K, Bose D, Cheng ZQ, Light RB.  N,N',N"-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs. Crit Care Med. 2004;32(1):184-93.

Mink SN, Simons FE, Simons KJ, Becker AB, Duke K.  Constant infusion of epinephrine, but not bolus treatment, improves haemodynamic recovery in anaphylactic shock in dogs. Clin Exp Allergy. 2004;34(11):1776-83.

Regula KM, Baetz D, Kirshenbaum LA.  Nuclear factor-kappaB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes. Circulation. 2004;110(25):3795-802.

Regula KM, Rzeszutek MJ, Baetz D, Seneviratne C, Kirshenbaum LA.  Therapeutic opportunities for cell cycle re-entry and cardiac regeneration. Cardiovasc Res. 2004;64(3):395-401.

Roberts DE, McNicol A, Bose R.  Mechanism of collagen activation in human platelets. J Biol Chem. 2004;279(19):19421-30.