Current Topics:

• Which enzymes contribute to drug metabolism by acetylation?
• How are drugs transported into kidney tubules and across the blood-brain barrier?
• How does aging affect drug metabolism and efficacy?
• How are antimicrobial pharmacokinetics and pharmacodynamics related to clinical outcome?
• What are the clinical pharmacology characteristics of antiviral drugs

Faculty Involved:

Representative Publications (last 4 years):

2010

Chakravarthi, S.S., De, S., Miller, D.W., and Robinson, D.H.  (2010) Comparison of anti-tumor efficacy of paclitaxel delivered in PLGA nanospheres and microspheres.  Intl. J. Pharm. 383, 37-44.

Gufford, B.T., Sriraghavan, K., Miller, N.J., Gu, X., Miller, D.W., Vennerstrom J.L., and Robinson D.R. (2010) Physicochemical characterization of creatine N-methylguanidinium salts.  J. Dietary Supplements 7, 240-252.

Wang, T., Hasinof, B., Miller, D.W. and Gu, X.  (2010) Percutaneous permeation comparison of repellents Picaridin and DEET in concurrent use with sunscreen Oxybenzone from commercially available preparations. Pharmazie (in press).

2009

Mitchell, R.W., Edmundson, C., Miller, D.W., and Hatch, G.M.  (2009) On the mechanism of oleate transport across human brain microvessel endothelial cells. J. Neurochem. 110, 1049-1057. 

2006
Aoki FY, Tyring S, Diaz-Mitoma F, Gross G, Gao J, Hamed K.  Single-day, patient-initiated famciclovir therapy for recurrent genital herpes: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2006;42(1):8-13.

Farkas S, Hussein J, Ariano RE, Sitar DS, Hasan SU.  Prenatal cigarette smoke exposure: pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model. Toxicol Appl Pharmacol. 2006;214(2):118-25.

Goralski KB, Bose R, Sitar DS.  NH₄⁺ modulates renal tubule amantadine transport independently of intracellular pH changes. Eur J Pharmacol. 2006;541(1-2):87-94.

Grymonpre R, Cheang M, Fraser M, Metge C, Sitar DS.  Validity of a prescription claims database to estimate medication adherence in older persons. Med Care. 2006;44(5):471-7.

Hussein J, Farkas S, Mackinnon Y, Ariano RE, Sitar DS, Hasan SU.  Nicotine dose-concentration relationship and pregnancy outcomes in rat: Biologic plausibility and implications for future research. Toxicol Appl Pharmacol. 2006; [Epub ahead of print]

Vinh DC, Aoki FY.  Famciclovir for the treatment of recurrent genital herpes: a clinical and pharmacological perspective. Expert Opin Pharmacother. 2006;7(16):2271-86.

Wald A, Selke S, Warren T, Aoki FY, Sacks S, Diaz-Mitoma F, Corey L.  Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding. Sex Transm Dis. 2006;33(9):529-33.

2005
Ariano RE, Fine A, Sitar DS, Rexrode S, Zelenitsky SA.  Adequacy of a vancomycin dosing regimen in patients receiving high-flux hemodialysis. Am J Kidney Dis. 2005;46(4):681-7.

Ariano RE, Nyhlen A, Donnelly JP, Sitar DS, Harding GK, Zelenitsky SA.  Pharmacokinetics and pharmacodynamics of meropenem in febrile neutropenic patients with bacteremia. Ann Pharmacother. 2005;39(1):32-8.

Ariano RE, Zelenitsky SA, Nyhlen A, Sitar DS.  An evaluation of an optimal sampling strategy for meropenem in febrile neutropenics. J Clin Pharmacol. 2005;45(7):832-5.

Bachmeier CJ, Miller DW.  A fluorometric screening assay for drug efflux transporter activity in the blood-brain barrier. Pharm Res. 2005;22(1):113-21.

Bachmeier CJ, Spitzenberger TJ, Elmquist WF, Miller DW.  Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. Pharm Res. 2005;22(8):1259-68.

Bernstein DI, Aoki FY, Tyring SK, Stanberry LR, St-Pierre C, Shafran SD, Leroux-Roels G, Van Herck K, Bollaerts A, Dubin G; GlaxoSmithKline Herpes Vaccine Study Group.  Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccine. Clin Infect Dis. 2005;40(9):1271-81.

Sacks SL, Aoki FY, Martel AY, ShafranSD, Lassonde M.  Clinic-initiated, twice-daily oral famciclovir for treatment of recurrent genital herpes: a randomized, double-blind, controlled trial. Clin Infect Dis. 2005;41(8):1097-104.

Sitar DS.  Old drugs - old people - new insights. Can J Clin Pharmacol. 2005;12(1):e28-32.

Zelenitsky SA, Iacovides H, Ariano RE, Harding GK.  Antibiotic combinations significantly more active than monotherapy in an in vitro infection model of Stenotrophomonas maltophilia. Diagn Microbiol Infect Dis. 2005;51(1):39-43.

2004
Bachmeier CJ, Trickler WJ, Miller DW.  Drug efflux transport properties of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF-AM) and its fluorescent free acid, BCECF. J Pharm Sci. 2004;93(4):932-42.

Green R, Sitar DS, Tenenbein M.  Effect of anticholinergic drugs on the efficacy of activated charcoal. J Toxicol Clin Toxicol. 2004;42(3):267-72.

Strijack C, Harding GK, Ariano RE, Zelenitsky SA.  Peritoneal fluid titer test for peritoneal dialysis-related peritonitis. Antimicrob Agents Chemother. 2004;48(5):1719-26.

Vercaigne LM, Ariano RE, Zacharias JM.  Bayesian pharmacokinetics of gentamicin in a haemodialysis population. Clin Pharmacokinet. 2004;43(3):205-10.

Wright SH, Evans KK, Zhang X, CherringtonNJ, Sitar DS, Dantzler WH.  Functional map of TEA transport activity in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2004;287(3):F442-51.

Zelenitsky SA, Iacovides H, Harding GK, Ariano RE.  Effect of antibiotic sequence on combination regimens against Pseudomonas aeruginosa in a multiple-dose, in vitro infection model. Diagn Microbiol Infect Dis. 2004;49(1):67-70.

2003
Aoki FY, Macleod MD, Paggiaro P, Carewicz O, El Sawy A, Wat C, Griffiths M, Waalberg E, Ward P; IMPACT Study Group.  Early administration of oral oseltamivir increases the benefits of influenza treatment. J Antimicrob Chemother. 2003;51(1):123-9.

Kabanov AV, Batrakova EV, Miller DW.  Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv Drug Deliv Rev. 2003;55(1):151-64.

Kolbe F, Sitar DS, Papaioannou A, Campbell G.  An amantadine hydrochloride dosing program adjusted for renal function during an influenza outbreak in elderly institutionalized patients. Can J Clin Pharmacol. 2003;10(3):119-22.

McGuire TR, Trickler WJ, Hock L, Vrana A, Hoie EB, Miller DW.  Release of prostaglandin E-2 in bovine brain endothelial cells after exposure to three unique forms of the antifungal drug amphotericin-B: role of COX-2 in amphotericin-B induced fever. Life Sci. 2003;72(23):2581-90.

Trickler WJ, Miller DW.  Use of osmotic agents in microdialysis studies to improve the recovery of macromolecules. J Pharm Sci. 2003;92(7):1419-27.

Zelenitsky SA, Ariano RE, Iacovides H, Sun S, Harding GK.  AUC(0-t)/MIC is a continuous index of fluoroquinolone exposure and predictive of antibacterial response for Streptococcus pneumoniae in an in vitro infection model. J Antimicrob Chemother. 2003;51(4):905-11.

Zelenitsky SA, Harding GK, Sun S, Ubhi K, Ariano RE.  Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis. J Antimicrob Chemother. 2003;52(4):668-74.

Zhang Y, Bachmeier C, Miller DW.  In vitro and in vivo models for assessing drug efflux transporter activity. Adv Drug Deliv Rev. 2003;55(1):31-51.