*Zherebitskaya, E., Akude, E., Smith, D.R. and P. Fernyhough (2009). Development of selective axonopathy in adult sensory neurons isolated from diabetic rats:  role of glucose
induced oxidative stress. . Diabetes. 58, 1356-1364. (if, 8.26) 

Malisza, K.L., Jones, C., Gruwel, M.L.H., Summers, R., Smith, D.R., P. Fernyhough and N.A. Calcutt (2009). Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. Journal of Magnetic Resonance Imaging. 30, 271-276. (if, 2.21)  

Smith, D., Tweed, C., Fernyhough, P. and G.W. Glazner (2009). Activation of NF-kB in axons and Schwann cells at site of sciatic nerve crush and role in modulating axon regeneration: studies with etanercept. Journal of Neuropathology and Experimental Neurology. 68, 691-700. (if, 4.72)

*Calcutt, N.A., Jolivalt, C.G. and P. Fernyhough (2008). Growth factors and therapeutics for diabetic neuropathy. Current Drug Targets. 9, 47-59. (if, 4.27)

*Verkhratsky, A. and P. Fernyhough (2008). Mitochondrial malfunction and Ca²⁺ dyshomeostasis drive neuronal pathology in diabetes. Cell Calcium. 44, 112-122. (if, 4.12)

 *Wang, Z., Gardiner, N.J. and P. Fernyhough (2008). Blockadeof hexokinase activity and binding to mitochondria inhibitsneurite outgrowth in cultured adult rat sensory neurons. Neuroscience Letters. 434, 6-11. (if, 2.1)

Brussee, V., Guo, G.F., Dong, Y.Y., Cheng, C., Martinez, J.A., Smith, D., Glazner, G.W., Fernyhough, P. and D.W. Zochodne (2008). Distal degenerative sensory neuropathy in a long term type 2 diabetes rat model. Diabetes. 57, 1664-1673. (if, 8.26)

Gardiner NJ, Moffatt S, Fernyhough P, Humphries MJ, Streuli CH, Tomlinson DR.Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin. Mol Cell Neurosci. 2007 Jun;35(2):249-60. Epub 2007 Mar 6.

Arboleda G, Huang TJ, Waters C, Verkhratsky A, Fernyhough P, Gibson RM. Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. Eur J Neurosci. 2007 May;25(10):3030-8. 

Fernyhough, P, Smith, D., Schapansky, J., Van Der Ploeg, R., Gardiner, N., Tweed, C., Kontos, A., Freeman, L., Purves-Tyson, T., and G. W. Glazner. (2005). Activation of NF-kB via endogenous TNF-alpha regulates survival of axotomized adult sensory neurons. J. Neuroscience 25(7) 1682-1690.

Gardiner, N.J., Fernyhough, P., Tomlinson, D.R., Mayer, U., von der Mark, H., and C.H. Streuli (2005) α7 integrin mediates axon regeneration of distinct populations of adult sensory neurons. Molecular and Cellular Neuroscience. Mol Cell Neurosci. 28(2):229-40.

Huang, T-J, Verkhatsky, A, and P. Fernyhough. (2005) Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensoryneurons. Molecular and Cellular Neuroscience. 28;42-54.
Middlemas, A., Delcroix, J.-D., Sayers, N.M., Tomlinson, D.R. and P. Fernyhough (2003). Enhanced activation of axonally transported stress-actived protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3. Brain 126, 1671-1682.

Fernyhough, P., Huang, T.Z. and A. Verkhratsky (2003). Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. Journal of the Peripheral Nervous System 8, 227-235.

Huang, T.-Z., Price, S., Chilton, L., Calcutt, N.A., Tomlinson, D.R., Verkhratsky, A. and P. Fernyhough (2003). Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of Type I diabetic rats in the presence of sustained hyperglycemia. Diabetes 52, 2129-2136.

Sayers, N.M., Beswick, L.J., Middlemas, A., Calcutt, N.A., Mizisin, A.P., Tomlinson, D.R. and P. Fernyhough (2003). Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin diabetic rats. Diabetes 52, 2372-2380.

Huang, T.-Z., Sayers, N.M., Fernyhough, P. and A. Verkhratsky (2002). Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3. Diabetologia 45, 560-570.

Fernyhough, P. and R. Schmidt (2002). Neurofilaments in diabetic neuropathy. Int. Rev. Neurobiol. 50, 115-144.

Glazner, G.W. and P. Fernyhough (2002). Neuronal survival in the balance: Are endoplasmic reticulum membrane proteins the fulcrum? Cell Calcium 32, 421-433.

Averill, S., Delcroix, J.-D., Michael, G.J., Tomlinson, D.R., Fernyhough, P. and J.V. Priestley (2001). Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Molecular and Cellular Neuroscience 18, 183-196.

Purves, T., Middlemass, A., Agthong, S., Jude, E., Boulton, A., Fernyhough, P. and D.R. Tomlinson (2001). A role for mitogen-activated protein kinases in the aetiology of diabetic neuropathy. FASEB Journal 15, 2508-2514.

Fernyhough, P., Gallagher, A., Averill, S., Priestley, J.V., Hounsom, L., Patel, J., and D.R. Tomlinson (1999). Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes 48, 881-889.

Delcroix, J.-D., Averill, S., Fernandes, K., Tomlinson, D.R., Priestley, J.V. and P. Fernyhough (1999). Nerve growth factor modulates axonal transport of the transcription factor ATF2 in sensory neurones. Journal of Neuroscience 19, RC24 (1-7).

Current Research group:

Dr. Ali Saleh – research associate (SBRC)
Dr. Savitha Balakrishnan – postdoctoral fellow (CIHR)
Dr. Subir Chowdhury – research associate (JDRF)
Dr. Elena Zherebitskaya – research associate (JDRF)
Mr. Randy Van Der Ploeg – technician (CIHR)
Mr. Eli Kwaku Akude – PhD student (NSERC)
Dr. Darrell Smith – PhD student (MHRC)
Mr. Jason Schapansky – technician (CIHR)
Miss. Emily Mutch – research assistant (JDRF)

Neurodiab meeting in Toronto, October 2009