• B.Sc. (Biology), Univ. of Toronto, 1975
• M.Sc. (Molecular Biology), Univ. of Toronto, 1976
• Ph.D. (Molecular Biology), Univ. of Toronto, 1981
• Postdoctoral Fellow (Physiology), Univ. of Manitoba, 1981-84
• Assistant Professor (Physiology), Univ. of Manitoba, 1984-91
• Associate Professor (Physiology), Univ. of Manitoba, 1991-2003
• Professor (Physiology), Univ. of Manitoba, 2004-present
• Head (Physiology), Univ. of Manitoba, 2004- 2012

In my laboratory we use transgenic mouse models to study the molecular events prostate cancer, in particular the progression of prostatic-intraepithelial neoplasia (PIN) to invasive adenocarcinoma. The influence of hormones, diet and micronutrints on tumor growth and progression are assessed with a view to developing preventive strategies for this common cancer.

Prostate Cancer: We employ three approaches to study the development, growth and progression of prostate cancer. 

1. Transgenic mouse models of prostate cancer in which expression of oncogenes, tumor suppressor and other genes are targeted to the prostate gland using prostate-specific promoter elements from the rat probasin gene. These transgenic models will facilitate the study of tumorigenesis in the prostate gland and the development of novel therapeutic approaches to prostate neoplasia.
2. Cell culture assays using human prostate cancer cell lines to examine signal transduction systems which contribute to growth regulation and metastatic potential. At present, we are investigating pathways mediated by the erbB family of growth factor receptors.
3. Molecular analyses of human prostate tumors to identify alterations in gene expression which may contribute to malignant transformation. These include tumor suppressor genes, cellular oncogenes, peptide growth factors and their receptors.

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