Research in my laboratory aims to investigate the pathogenesis of obesity and insulin resistance. One theme of investigation has been the role of the intrauterine milieu (e.g. alcohol consumption during pregnancy) as a cause of insulin resistance and type 2 diabetes in the offspring.

Another area of interest has been the role of adipocyte hormones (leptin, resistin, adiponectin) in obesity and the regulation of glucose homeostasis.

Insulin signaling and transcription factors involved in insulin action are being explored.

The ultimate goal is a better understanding of molecular mechanisms of insulin resistance and prevention of type 2 diabetes