Diabetes
Atherosclerosis
Thrombosis
Fibrinolysis
Lipids and lipoproteins
Transcriptional and signal transduction mechanism
Oxidative stress
Anti-diabetes and anti-thrombotic drug development
Gestational diabetes and child growth
Lifestyle intervention

Selective Publications:

Aljohani N, Rempel BM, Ludwig S, Morris M, McQuillen K, Cheang M, Murray R, Shen GX. Gestational diabetes in Manitoba during a twenty-year period Clin Invest Med 2008;31:E131-E137

Zhao R, Ma X, Shen GX Transcriptional Regulation of Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells Induced by Oxidized Very Low density Lipoproteins Mol Cell Biochem 2008;317:197-204

Sangle G, Zhao R, Shen GX Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of expression of plasminogen activator inhibitor-1 in vascular endothelial cells Am J Physiology: Endocrin Metab 2008;295:E1243-E1254

Aljohani N, Rempel BM, Ludwig S, Morris M, Cheang M, Murray R, Bruce S, Shen GX Impact of gestational diabetes on maternal-fetal outcomes: a retrospective cohort study in Manitoba. Clin Invest Med 2008;31:E338-E345

Zhao R, Ma X, Xie X, Shen GX Involvements of NADPH oxidiase in oxidized LDL-induced upregulation of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells Am J Physiology: Endocrin Metab 2009;297:E104-E111

Roy Chowdhury SK, Sangle GV, Xie X, Halayko AJ, Stelmark G, Shen GX Effect of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab. 2010;298:E89-98.

Tang XF, Liu JJ, Wu YL, Chen KM, Jin Y, Gao PJ, Zhu DL, Shen GX Effect of hirulog-like peptide on balloon catheter injury induced neoinitimal formation in femoral arteries of minipigs J Vasc Res 2010;47:262-269.

Sangle GV, Roy Chowdhury SK, Xie X, Halayko AJ, Stelmark G, Shen GX Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated LDL Free Radical Biology and Medicine. 2010;48:781-790

Sangle GV, Shen GX Signaling mechanisms for oxidized LDL-induced oxidative stress and the upregulation of plasminogen activator inhibitor-1 in vascular cells Clin Lipidology 2010;5:221-232 Shen GX Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase Can J Pharmacol Physiol 2010;88:241-248

Sangle GV, Zhao R, Misuno T, Shen GX Involvement of RAGE, NADPH oxidase and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells Endocrinology 151:4455-66