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Research Interests:
Our laboratory is interested in mechanisms of
platelet activation and secretion. Over the last
several years we have examined various aspects of
dense granule secretion including identification
of dense granule membrane proteins, and the
clinical correlate, storage pool deficiency. We
are also examining the platelet function in
newborns and premature infants whose platelets
demonstrate evidence of decreased signal
transduction in response to a variety of stimuli.
Recent Publications
- McNicol, A., Philpott, C.L., Shibou, T.S.,
Israels, S.J. Effects of the mitoen-activated protein (MAP) kinase
kinase inhibitor
2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one
(PD98059) on human platelet activation. Biochem.
Pharmacol. 55:1759-67,
1998. PMID
9714293
- Israels, S.J., Odaibo, F.S., Robertson,
C., McMillan E.M., McNicol, A. Deficient
thromboxane synthesis and response in
platelets from premature infants. Pediatr.
Res. 41:218-23, 1997. PMID
9029642
- S.J. Israels, E.M. McMillan, C.
Robertson, S. Singhroy,A. McNicol. The
lysosomal granule membrane protein,
LAMP-2, is also present in platelet dense
granule membrane. Thromb. and
Haemos. 75:623, 1996. PMID
8743190
- McNicol, S.J. Israels, C. Robertson, J.
M. Gerrard.The empty sack syndrome: A
platelet storage pool deficiency
associated with empty dense granules. A. Br.
J. Haematol. 86:574,1994.
PMID
94318472
PubMed
Listed Publications
Lab Members:
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