Saman Muthukumarana

University of Manitoba, Department of Statistics

“Meta-analytic Methods using Dirichlet Process”

Date: Thursday, March 23, 2017

In many scientific disciplines, it is common to find large number of studies addressing the same research question of interest. Meta-analysis can be used for combining or contrasting the results from these multiple studies. We develop a Bayesian approach for meta-analysis using Dirichlet process. The key aspect of the Dirichlet process in meta-analysis is the ability to assess the evidence of statistical heterogeneity in the underlying effects across studies while relaxing the distributional assumptions. Assuming that the study effects are generated from a Dirichlet process, the study effects parameters have support on a discrete space and enable borrowing of information across studies while facilitating clustering among studies. We also extend the approach for binary data in the presence of excessive zeros and propose a modified unconditional odds ratio which accounts for excessive zeros. Results from the data analyses, simulation studies, and the log-pseudo marginal likelihood (LPML) model selection procedure indicate that the proposed models perform better than conventional alternative methods. Some extensions to network meta-analysis will also be discussed.

Important Dates

March 31: Last date for Voluntary Withdrawal (VW) from Winter Term and Fall/Winter Term spanned courses.

April 3: Summer Term registration begins

Upcoming Exams

STAT 3400 A01 Midterm 2
Monday, March 27 at 2:30 p.m.

STAT 2400 A01 Midterm 2
Wednesday, April 5 at 2:30 p.m.

Upcoming Seminars

Statistics seminar: Lei Sun: “Testing a vector of parameters with applications to genetic association studies” — Thursday, March 30 at 2:45 p.m., 527 Buller.

Statistics seminar: Eugene Huang: “Restoration of Monotonicity Respecting in Dynamic Regression” — Thursday, April 6 at 2:45 p.m., 527 Buller.

Data talk: Ehsan Khafipour — Thursday, April 13 at 2:45 p.m., 527 Buller.

Statistics seminar: Saumen Mandal — Thursday, April 20 at 2:45 p.m., 527 Buller.

Where are they now?

Dankit K. Nassiuma, Ph.D. (1992)

Robert Tate, M.Sc. (1975)