A
variety of medications have been tried in the treatment of Spasmodic
Torticollis (ST). These include anticholinergics, dopaminergics, and
benzodiazepines.
Drugs in the anticholinergic group include
trihexyphenidyl (Artane), biperiden (Akineton), cycrimine (Pagitane)
and benztropine (Cogentin). They are usually required in large doses
for effective relief of spasms. About half of ST sufferers cannot tolerate
the side effects of these medications.
Dopaminergic drugs include levodopa (Sinemet
or Madopar), bromocriptine (Parlodel), and amantadine (Symmetrel). They
are only effective in certain cases. The benzodiazepine group includes
diazepam (Valium) and flunitrazepam.
Medications are usually the first line
of treatment, because they are the most convenient for the patient,
(ie. they cost the least, are easily administered and are the least
invasive). Unfortunately, most patients do not find satisfying long-term
relief with these drugs, and other forms of treatment are considered.
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