Research Institute in Oncology and Hematology

Dr Ryan Zarychanski

Blood Disorders and Transfusion Medicine

Dr Ryan Zarychanski MD MSc FRCPC
2056-675 McDermot Ave
Winnipeg, MB R3E 0V9
Email: Dr Ryan Zarychanski MD MSc FRCPC


Research Program

Dr. Ryan Zarychanski is an Assistant Professor and Clinician-Scientist at the University of Manitoba in the Department of Medicine, Sections of Critical Care and of Hematology/Medical Oncology. Following subspecialty fellowships Hematology and Critical Care Medicine, he obtained a Masters degree in Epidemiology and Community Medicine, and undertook a research fellowship at the University of Ottawa. Dr. Zarychanski’s research focuses on the hematologic aspects of critical illness. Major programs of research include evaluating efficacy and safety of heparin and IVIG in patients with septic shock. Recent research includes evaluating processes of care in massive transfusion and investigating blood products and blood conservation in the critically ill.

Dr. Zarychanski is the Director of Knowledge Synthesis at the Centre for Healthcare Innovation in Winnipeg, Manitoba and was awarded the Lyonel G. Israels Professorship in Hematology from the University of Manitoba in 2016 and the Canadian Institute of Health Research (CIHR) New Investigator Award in 2014.

Publication since 2011

Accepted or in Press
  • Fiest KM, Bernstein CN, Walker JR, Graff LA, Hitchon CA, Peschken CA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton J, Marrie RA. Systematic Review and Meta-Analysis of Interventions for Depression and Anxiety in Persons with Rheumatoid Arthritis. Journal of Clinical Rheumatology. 2016
  • Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson DA, Moore L, McIntyre LA, Archambault P, Légaré F, Rousseau F, Lamontagne F, Nadeau L, Turgeon AF. Predictive value of neuron-specific enolase (NSE) for prognosis in patients with moderate or severe traumatic brain injury: A systematic review and meta-analysis. CMAJ Open. 2016; February.
  • Ducas RA, Labos C, Allen D, Golian M, Jeyaraman M, Lys J, Mann A, Copstein L, Vokey S, Rabbani R, Zarychanski R, Abou-Setta AM, Menkis A. Association of pre-hospital ECG administration with clinical outcomes in ST-segment myocardial infarction: a systematic review and meta-analysis. Canadian Journal of Cardiology. 2016
PubMed Listed Publications
**ALL CAPS denotes research supervisor to trainees

  1. Chemoradiotherapy versus radiotherapy alone in elderly patients with stage III non-small cell lung cancer: a systematic review and metaanalysis. Dawe DE, Christiansen D, Swaminath A, Ellis PM, Rothney J, Rabbani R, Abou-Setta AM, Zarychanski R; Mahmud SM. Lung Cancer. 2016 Sept;99:180-185. PMID: 27565937
  2. Systematic review of interventions for depression and anxiety in persons with inflammatory bowel disease. Fiest KM, Bernstein CN, Walker JR, Graff LA, Hitchon CA, Peschken CA, Zarychanski R, Abou-Setta A, Patten SB, Sareen J, Bolton J, Singer A, Marrie RA; CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease”. BMC Research Notes. 2016 Aug 12;9(1):404. doi: 10.1186/s13104-016-2204-2. PMID: 27514366
  3. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. Crit Care. 2016 Mar 30;20:75.
  4. New modalities to deliver surfactant in premature infants: a systematic review and meta-analysis. Ali E, Abdel Wahed M, Alsalami Z, Abouseif H, Gottschalk T, Rabbani R, Zarychanski R, Abou-Setta AM. J Matern Fetal Neonatal Med. 2016 Nov;29(21):3519-24. doi: 10.3109/14767058.2015.1136997. Epub 2016 Feb 10.
  5. Resuscitation Prior to Emergency Endotracheal Intubation: Results of a National Survey. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. West J Emerg Med. 2016 Sep;17(5):542-8. doi: 10.5811/westjem.2016.6.30503. Epub 2016 Jul 26.
  6. Device and Medication Preferences of Canadian Physicians for Emergent Endotracheal Intubation in Critically Ill Patients. Green RS, Fergusson DA, Turgeon AF, McIntyre LA, Kovacs GJ, Griesdale DE, Zarychanski R, Butler MB, Kureshi N, Erdogan M. CJEM. 2016 Aug 30:1-12. [Epub ahead of print]
  7. Systematic review of interventions for depression and anxiety in persons with inflammatory bowel disease. Fiest KM, Bernstein CN, Walker JR, Graff LA, Hitchon CA, Peschken CA, Zarychanski R, Abou-Setta A, Patten SB, Sareen J, Bolton J, Singer A, Marrie RA; CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease”. BMC Res Notes. 2016 Aug 12;9(1):404. doi: 10.1186/s13104-016-2204-2.
  8. Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes. Gould TJ, Lysov Z, Swystun LL, Dwivedi DJ, Zarychanski R, Fox-Robichaud AE, Liaw PC; Canadian Critical Care Translational Biology Group. Shock. 2016 Jul 11. [Epub ahead of print]
  9. Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock. McIntyre L, Rowe BH, Walsh TS, Gray A, Arabi Y, Perner A, Gordon A, Marshall J, Cook D, Fox-Robichaud A, Bagshaw SM, Green R, Schweitzer I, Turgeon A, Zarychanski R, English S, Chassé M, Stiell I, Fergusson D; Canadian Critical Care Trials Group. BMJ Open. 2016 Jul 7;6(7):e010041. doi: 10.1136/bmjopen-2015-010041.
  10. Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism. Ihaddadene R, Corsi DJ, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Solymoss S, Routhier N, Douketis J, Le Gal G, Carrier M. Blood. 2016 Apr 21;127(16):2035-7. doi: 10.1182/blood-2015-11-682963. Epub 2016 Jan 27.
  11. Early Exposure to Nonnutritive Sweeteners and Long-term Metabolic Health: A Systematic Review. Reid AE, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Abou-Setta AM, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R, Azad MB. Pediatrics. 2016 Mar;137(3):e20153603. doi: 10.1542/peds.2015-3603. Epub 2016 Feb 25. Review.
  12. The prognostic value of magnetic resonance imaging in moderate and severe traumatic brain injury: a systematic review and meta-analysis protocol. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R, Fergusson D, Turgeon AF. Syst Rev. 2016 Jan 19;5:10. doi: 10.1186/s13643-016-0184-x.
  13. Coronary artery bypass surgery in a patient with Haemophilia A: a case report. Menard CE, Zawadski D, Singal RK, Rimmer E, Houston DS, Houston BL, Zarychanski R. Haemophilia. 2016 Jan;22(1):e76-9. doi: 10.1111/hae.12864. Epub 2015 Dec 3. No abstract available.
  14. Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Fiest KM, Walker JR, Bernstein CN, Graff LA, Zarychanski R, Abou-Setta AM, Patten SB, Sareen J, Bolton JM, Marriott JJ, Fisk JD, Singer A, Marrie RA; CIHR Team Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease. Mult Scler Relat Disord. 2016 Jan;5:12-26. doi: 10.1016/j.msard.2015.10.004. Epub 2015 Oct 19. Review.
  15. Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Griesdale D, Desjardins P, Lacroix J, Fergusson D, Turgeon AF. Transfus Med Rev. 2016 Jan;30(1):15-24. doi: 10.1016/j.tmrv.2015.08.004. Epub 2015 Aug 28. Review.
  16. Intermittent vs Continuous Androgen Deprivation Therapy for Prostate Cancer: A Systematic Review and Meta-analysis. Magnan S, Zarychanski R , Pilote L, Bernier L, Shemilt M, Vigneault E, Fradet V, Turgeon AF. JAMA Oncol. 2015 Sep 17:1-10. doi: 10.1001/jamaoncol.2015.2895. [Epub ahead of print]
  17. SOME Investigators.Screening for Occult Cancer in Unprovoked Venous Thromboembolism. Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R , Solymoss S, Routhier N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi DJ, Ramsay T, Coyle D, Chagnon I, Kassam Z, Tao H, Rodger MA; N Engl J Med. 2015 Aug 20;373(8):697-704. doi: 10.1056/NEJMoa1506623. Epub 2015 Jun 22.
  18. Severe Rh alloimmunization and hemolytic disease of the fetus managed with plasmapheresis, intravenous immunoglobulin and intrauterine transfusion: A case report. Houston BL, Govia R, Abou-Setta AM, Reid GJ, Hadfield M, Menard C, Noyd J, Main S, Zarychanski R . Transfus Apher Sci. 2015 Aug 7. pii: S1473-0502(15)00146-9. doi:10.1016/j.transci.2015.07.010. [Epub ahead of print]
  19. The authors reply. Zarychanski R , Kumar A. Crit Care Med. 2015 Jun;43(6):e213. doi: 10.1097/CCM.0000000000001032. No abstract available.
  20. Critical care capacity in Canada: results of a national cross-sectional study. Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon AF, Lamontagne F, Kumar A, Zarychanski R , Green R, Bagshaw SM, Stelfox HT, Foster R, Dodek P, Shaw S, Granton J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P; Canadian Critical Care Trials Group; Canadian ICU Capacity Group. Crit Care. 2015 Apr 1;19:133. doi: 10.1186/s13054-015-0852-6.
  21. The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Zarychanski R , Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA; Canadian Critical Care Trials Group. Crit Care Med. 2015 Mar;43(3):511-8. doi: 10.1097/CCM.0000000000000763. Review.
  22. PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators.Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Lim W, Meade M, Lauzier F, Zarychanski R , Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; Crit Care Med. 2015 Feb;43(2):401-10. doi: 10.1097/CCM.0000000000000713.
  23. The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis. Rimmer E, Houston BL, Kumar A, Abou-Setta AM, Friesen C, Marshall JC, Rock G, Turgeon AF, Cook DJ, Houston DS, Zarychanski R . Crit Care. 2014 Dec 20;18(6):699. doi: 10.1186/s13054-014-0699-2.
  24. Association between arterial catheter use and hospital mortality in intensive care units. Gershengorn HB, Wunsch H, Scales DC, Zarychanski R , Rubenfeld G, Garland A. JAMA Intern Med. 2014 Nov;174(11):1746-54. doi: 10.1001/jamainternmed.2014.3297.
  25. Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis. Manyanga T, Froese M, Zarychanski R , Abou-Setta A, Friesen C, Tennenhouse M, Shay BL. BMC Complement Altern Med. 2014 Aug 23;14:312. doi: 10.1186/1472-6882-14-312. Review.
  26. The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients. KUMAR K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC on behalf of the Cardiovascular Health Research in Manitoba Investigator Group. Journal of Thoracic and Cardiovascular Surgery. Mar 2. pii: S0022-5223(14)00282-7. doi: 10.1016/j.jtcvs.2014.02.074. [Epub ahead of print] PMID: 24703332
  27. Methotrexate and trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Canadian Family Physician. 2013. PMID: 24452563
  28. Probiotic Supplementation During Pregnancy or Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R (senior author/supervisor). British Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677
  29. Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P, Zarychanski R. (senior author/supervisor). Journal of Clinical Apheresis. 2013. doi: 10.1002/jca.21309. [Epub ahead of print] PMID: 24265247
  30. Challenges of population-based colorectal cancer screening and the importance of time-trend analysis when evaluating system change. Zarychanski R, Dennis J, Singh H. Cancer Epidemiology. 2013;37:957-958 [Editorial]. PMID: 24210585
  31. Canadian Critical Care Trials Group H1N1 Collaborative. Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study. Bagshaw SM1, Sood MM, Long J, Fowler RA, Adhikari NK; BMC Nephrol. 2013 Jun 13;14:123. doi: 10.1186/1471-2369-14-123. PMID: 23763900
  32. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease? Goldenberg BA, Graff LA, Clara I, Zarychanski R, Walker JR, Carr R, Rogala L, Miller N, Bernstein CN. American Journal of Gastroenterology. 2013;108:1392-1397. PMID: 24005345
  33. The use of higher Platelet:RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic review. Hallet J, Lauzier F, Mailloux O, Trottier V, Archambault P, Zarychanski R, Turgeon AF. Critical Care Medicine. 2013;41 [Epub ahead of print]. PMID: 23982024
  34. Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. Lauzier F, Arnold DM, Rabbat C, Heels-Ansdell D, Zarychanski R, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes RD, Zytaruk N, Finfer S, Crowther M, Cook D - For the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Intensive Care Medicine. 2013;39:2135-2143. PMID: 23942857
  35. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors and outcomes. Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook DJ. Chest. 2013; Jun 20. [Epub ahead of print]. PMID: 23788287
  36. Effectiveness of human recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients: Randomized clinical trial versus nonrandomized study. RIMMER E, Kumar A, Zarychanski R* (*senior author/supervisor). Critical Care Medicine. 2013;7:e139-40 [Author Reply]. PMID: 23774364
  37. Meta-analyses of hydroxyethyl starch for volume resuscitation. Zarychanski R, Turgeon AF, Abou-Setta AM. Journal of the American Medical Association/JAMA. 2013;309:2209 [Author Reply]. PMID: 23736723
  38. Helmet Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis. Dennis J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). British Medical Journal/BMJ. 2013;346:f2674. PMID: 23674137
  39. Predictive value of S-100ß protein for prognosis in patients with moderate and severe traumatic brain injury: A systematic review and meta-analysis. Mercier E, Boutin A, Lauzier F, Fergusson DA, Simard JF, Zarychanski R, Moore L, McIntyre LA, Archambault P, Lamontagne F, Légaré F, Randell E, Nadeau L, Rousseau F, Turgeon AF. British Medical Journal/BMJ. 2013;346:f1757. PMID: 23558282
  40. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA. Journal of the American Medical Association/JAMA. 2013 Feb 20;309(7):678-88. PMID: 23423413
  41. Determination of neurological prognosis and clinical decision-making in adult patients with severe traumatic brain injury: A survey of Canadian intensivists, neurosurgeons and neurologists. Turgeon AF, Lauzier F, Burns KEA, Meade MO, Scales DC, Zarychanski R, Moore L, Zygun DA, McIntyre LA, Kanji S, Hébert PC, Murat V, Pagilarello G, Furgusson DA. Critical Care Medicine. 2013;41:1086-93. PMID: 23385104
  42. Factors associated with the withdrawal of life-sustaining therapies in patients with severe traumatic brain injury: A multicenter cohort study. Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE, Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA. Neurocrit Care. 2013;18:154-60. PMID: 23099846
  43. Anemia: Adaptive mechanisms and consequences. Zarychanski R, Rimmer E, Houston DS. (September 2012) In: eLS 2012, John Wiley & Sons Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0002157.pub2].
  44. Activated protein C and septic shock. A propensity matched cohort study. RIMMER E, Kumar A, Doucette S, Zarychanski R (senior author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Critical Care Medicine. 2012;40:2974-2981. PMID: 22932397
  45. Preoperative anemia does not increase the risks of early surgical revascularization following myocardial infarction. Zhang L, Hiebert B, Zarychanski R, Arora RC, and the Cardiovascular Health Research in Manitoba Investigator Group. Annals of Thoracic Surgery. 2013;95:542-547.
  46. PMID: 22939451
  47. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG. Blood. 2012;120(9):1908-1915. PMID: 22529292
  48. Effect of systemic steroids on post-tonsillectomy bleeding and reinterventions: a meta-analysis of randomized control trials. Plante J, Turgeon AF, Vigneault L, Lauzier F, Moore L, Zarychanski R, Boutin A, Nicole PC, Fergusson DA. British Medical Journal/BMJ 2012;345:e5389. PMID: 22930703
  49. Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies. Desjardins P, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Boutin A, Moore L, McIntyre LA, English SW, Rigamonti A, Lacroix J, Fergusson DA. Critical Care Forum 2012;16(2):R54. PMID: 22471943
  50. The PRECISE RCT: Evolution of an early septic shock fluid resuscitation trial. McIntyre L, Fergusson DA, Rowe B, Cook DJ, Arabi Y, Bagshaw SM, Emond M, Finfer S, Fox-Robichaud A, Gray A, Green R, Hebert P, Lang E, Marshall J, Stiell I, Tinmouth A, Pagliarello J, Turgeon AF, Walsh T, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group. Transfusion Medicine Reviews. 2012;26:333-341. PMID: 22222146
  51. Fluid Resuscitation with 5% Albumin versus Normal Saline in Early Septic Shock (PRECISE): A Pilot Randomized Controlled Trial. McIntyre L, Fergusson DA, Cook DJ, Rowe BH, Bagshaw S, Easton D, Emond M, Finfer S, Fox-Robichaud A, Gaudert C, Green R, Hebert PC, Marshall J, Rankin N, Stiell I, Tinmouth A, Pagliarello J, Turgeon AF, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group. Journal of Critical Care. 2012;27:317.e1-6. PMID: 22176806
  52. Transfusion thresholds in high-risk patients after hip surgery. Houston DS, Zarychanski R. New England Journal of Medicine/NEJM. 2012;366:1253 [Letter]. PMID: 22455422
  53. If at first you don't succeed: Try, try again. SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R (senior author/supervisor). American Journal of Hematology. 2012;87:295-7. PMID: 22086437
  54. Sedation and analgesia usage in severe H1N1 (2009) infection: A comparison to respiratory failure secondary to other infectious pneumonia. Olafson K, Ramsey C, Kumar A, Stasiuk A, Ariano R, Siddiqui F, Wong D, Guinn A, Braun J, Zarychanski R (senior author/supervisor). Annals of Pharmacotherapy. 2012;46:9-20. PMID: 22170974
  55. Refinement of the hereditary xerocytosis locus on chromosome 16q in a large Canadian kindred. HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Gallagher PG, Houston DS, Zarychanski R (senior author/supervisor). Blood Cells, Molecules and Diseases. 2011;47(4):226-231. PMID: 21944700
  56. Impact of critical care outreach on hematopoietic stem cell transplant recipients: a cohort study. Hayani O, Al-Beihany A, Chou A, Zarychanski R, Kharaba A, Baxter A, Petal R, Allan D. Bone Marrow Transplantation. 2011;46:1138-1144. PMID: 20972465
  57. From mice to men: Treating sepsis with heparin. Zarychanski R. Critical Care Medicine. 2011;39:1225-6 [Editorial]. PMID: 21610590
  58. Survival of trauma patients after massive red blood cell transfusion using a high or low red blood cell to plasma transfusion ratio. Rajasekhar A, Gowing R, Zarychanski R, Arnold D, Lim W, Crowther M, Lottenberg R. Critical Care Medicine. 2011; 39 epub ahead of print. PMID: 21336132
  59. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Vigneault L, Turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nicole PC, Fergusson DA. Canadian Journal of Anesthesia. 2011;58:22-37. PMID: 21061107



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