Research Interests:I received my Bachelor's degree at the University of British Columbia, Department of Microbiology and Immunology, where I became fascinated with the complex inter-workings of the immune response against pathogens. This motivated me to pursue my graduate studies in the laboratory of Dr. Eleanor Fish at the University of Toronto, where I uncovered a new chemotactic signaling pathway in T lymphocytes that played a role in generating an effective immune response against viral infections. I then started my postdoctoral fellowship under Dr. Thorsten Mempel at Massachusetts General Hospital (MGH) in Boston to enter the rapidly evolving field of multiphoton intravital microscopy (MP-IVM), utilizing this imaging technology to investigate the dynamics of HIV pathogenesis in vivo using humanized mice. As the new GSK Research Chair in Immunobiology of Infectious Diseases with the Departments of Immunology and Medical Microbiology, my scientific interests will continue to focus on understanding how the interplay between the host immune system and the microbial world dictates whether a pathogen is cleared or allowed to persist. By utilizing an in vivo imaging approach, I hope to uncover new findings on how the localization, phenotypic characteristics, and dynamic behaviors of immune cells within tissues shape the immune response during an infection, and to translate these observations into the design of effective, long-lasting vaccine strategies.
For a list of Dr. Murooka's PubMed articles, please click here