Conference Program

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CONFERENCE PROGRAM

JUNE 4, 1999

0700-0750 - "Meet the Professor" Session

Dr. John Embil, Director Foot clinic at Health Sciences Centre, will discuss:
Amputation Prevention and Rehabilitation in Diabetes.
Sponsored by Bayer.

    0800 - 0950 - Concurrent Symposia

    1. EPIDEMIOLOGY OF DIABETES MELLITUS

    Chairs: Kue Young and Jamie Blanchard

    "The Prevalence of Cardiovascular Disease in Women"
        Erika Froelicher (San Francisco)

    "The Prevalence of Diabetes in Canada"
        Jamie Blanchard (Winnipeg)

    "Incidence and Prevalence of Type 2 Diabetes in the Younth
      in Manitoba, Canada 1984 - 1998"
        Heather Dean (Winnipeg)

    "Undiagnosed Diabetes: Does it Matter?"
      
    Kue Young (Winnipeg)

    Sponosred by Dairy Farmers of Canada

    1. ENDOTHELIAL FUNCTION AND DIABETES

    Chairs Dennis McNamara and Avrum Gotlieb

    "Molecular Mechanisms of Endothelial Dysfunction in the Diabetic Heart"
        Peter Rösen (Dusseldorf)

    "Endothelial Integrity and Repair"
      
    Avrum I. Gotlieb (Toronto)

    "Hyperglycemia and Vascular Injury in the Alloxan-Induced Rabbit"
        Dennis B. McNamara (New Orleans)

    "Vasoactive Factors in the Diabetic Heart and Microvasculature"
      
    Subrata Chakrabarti (London, ON)

    1000 - 1030 - Coffee/Exhibits

    1030 - 1220 Concurrent Symposia

    1. GENETIC DETERMINANTS IN DIABETES AND VASCULAR RISK 

    Chairs: Nobuakira Takeda and Lorrie Kirshenbaum

    "Genetic Dissection of Atherosclerosis"
        Robert Hegele (London, ON) 

    "Homocysteine as a Risk Factor in Cardiovascular Disease"
        David Cole (Toronto) 

    "Cardiac Gene Expression in the Diabetic Heart"
        Nobuakira Takeda (Tokyo)

    "On the Role of Glucose-Induced Signaling and Changes in Protein Expression in the
      Evolution of   Diabetic Cardiomyopathy"
        Jos. M. J. Lamers (Rotterdam)

    1. INSULIN ACTION AND INSULIN RESISTANCE

    Chairs: David Brindley and Ian Dixon

    "The Mechanisms of Insulin Action"
        Barry I. Posner (Montreal)


    "Interaction of the Tumor Necrosis Factor-a  with Insulin Signaling"
        David Brindley (Edmonton)

    "Type 2 Diabetes: Pharmacological Intervention in Animal Models"
        J. C. Russel (Edmonton)

     "Insulin Resistance and Cardiovascular Disease in Asian Indians:
        Ramesh Goyal (Ahmedabad)

    Sponsored by SmithKline Beecham

  1. PUBLIC HEALTH SURVEILLANCE OF HEART DISEASE, STROKE AND DIABETES

Chairs: Sora Ludwig (Canadian Diabetes Foundation)
            Elinor Wilson (Heart and Stroke Foundation of Canada)


"Surveillance"is the on-going, systematic collection, analysis, interpretation and dissemination of health data to those who need to know.  This information is then used for planning, implementing and evaluating health interventions at local provicial and national levels.  Surveillance data are used to determine the need for (public) health action and to assess the effectiveness of programs.

Speakers:
                "Diabetes Surveillance in the United States"
                    Linda Geiss, US Center for Disease Control

                "Cardiovascular Disease and Diabetes in Sub-Saharan Africa"
                    Terry Aspray, Royal Victoria Infirmary, UK

                "Canadian Heart and Stroke Surveillance System"
                    Maureen Carew, Health Canada, Ottawa

                "The National Diabetes Surveillance System (1997 - Present): Goals,
                   Structure and Achievements to Date"
                    Sheila Chapmean, Health Canada, Ottawa

Sponsored by Laboratory Centre for Disease Control

1230 - 1330 - Poster Sessions - Lunch

1330 - 1520 - Concurrent Symposia

  1. DIABETES MELLITUS IN ETHNIC GROUPS     [News Release]

      Chairs: Bernard Zinman and Prakash Deedwania

      "Prevalence and Impact of Diabetes in a Canadian Native Community:
        The Sandy Lake Health and Diabetes Project"
          Bernard Zinman (Toronto)     [Abstract]

      "Diabetes and and Cardiovascular Disease in Hispanic and Native Americans in the U.S."
          Michael P. Stern (San Antonio)     [Abstract]

      "Diabetes, Insulin Resistance and Cardiovascular Disease in Asian Indians"
          Prakash Deedwania (San Francisco)     [Abstract]

    1. OXIDATIVE STRESS AND THE ROLE OF ANTIOXIDANTS

      Chairs: Pawan Singal and Saroj Sharma

      "Oxidative Stress and Functional Deficit in Diabetic Cardiomyopathy"
          Pawan Singal (Winnipeg)

      "Low Density Lipoprotein Oxidation, Diabetes and Endothelial Function"
          Ricky Man (Hong Kong)

      "Oxidative Stress, Vitamin E and Cardiovascular Disease Risk Factors in Diabetes"
          Sushil K. Jain (Shreveport)

      "Modified Lipoproteins and Cardiovascular Risk"
          Jiri Frohlich (Vancouver)

      Sponsored by Merck Frosst

      1530 - 1720 - Concurrent Symposia

    1. GLYCEMIC CONTROL AND VASCULAR PROTECTION

      Chairs: Jean Louis Chiasson and Stephen Schaffer

      "Insulin Treatment Post Myocardial Infarction: The DIGAMI Study"
          Klas Malmberg (Stockholm)

      "Implications of UKPDS Trial"
          Jean Louis Chiasson (Montreal)

      "Protection Against Ischemic and Hypoxic Injury by Diabetes and High Glucose Treatment"
          Stephen Schaffer (Mobile)

      "Plasma Glucose - A Continuous Risk Factor for Vascular Disease in both Diabetic
        and Non-Diabetic People"
          Hertzel Gerstein (Hamilton)

    1. LIPIDS AND LIPOPROTEINS     [News Release]

    2. Chairs: George Steiner and Patrick Choy

      "Advances in Lipid Lowering Therapy in Atherosclerosis"
          Jean Davignon (Montreal)

      "Lipoproteins, Diabetes and Coronary Artery Disease"
          Jacques G. Genest Jr. (Montreal)

      "The Role of Omega 3 Fatty Acids in Heart Health"
          Bruce Holub (Guelph)     [Abstract]

      "Lipoproteins Disorders in Diabetes: Rationale and Approach to Therapy"
          George Steiner (Toronto)

      Sponsored by SmithKline Beecham

      WORKSHOP I

      EXERCISE, FITNESS AND NUTRITION IN DIABETES AND HEART HEALTH

      Chair:   Michele Meade

      "Food Strategies for Diabetes and Heart Disease"
          Kathryn Camelon  (Toronto)

      "Strategies for Exercise and Fitness in Diabetes and Heart Health"
          Linda Smyrski (East St. Paul, MB)

      "Issues and Opportunities - Future Directions"
          Michele Meade (Winnipeg)

      Sponsored by Diary Farmers of Canada

       

      CONFERENCE PROGRAM

      JUNE 5, 1999

      0700-0750 - "Meet the Professor" Session II

      Moderator: Brian Penner

      Dr. George Carruthers, Professor and Chair Medicine, University of Western Ontario,
      will address "Hypertension Management: Drugs of Choice".

      Sponsored by Astra Canada

      0800 - 0950 - Concurrent Symposia

    3. HYPERTENSION MANAGEMENT IN DIABETES

    4. Chairs: George Carruthers and Bal K. Sharma

      "Hypertension, Its Management and Outcomes"
          George Carruthers (London, ON)     [Abstract]

      "The Effect of Hypertension on Diabetes Outcomes"
          Ellen Burgess (Calgary)     [Abstract]

      "Insulin and Endothelial Function: Diabetes and Hypertension"
          John McNeill (Vancouver)     [Abstract]

      "Cost Effectiveness of Blood Pressure Monitoring and Control"
          Arun Chockalingam (Ottawa)     [Abstract]

      Sponsored by Merck Frosst

    5. CELL SIGNALING IN DIABETES

    6. Chairs: Vincenzo Panagia and Bohuslav Ostandal

      "Alteration in G-Protein-Linked Signal Transduction in Vascular Smooth Muscle in Diabetes"
          M. B. Anand-Srivastava (Montreal)

      "Cyclic Nucleotides Phosphodiosterase Families in Intracellular Signaling and Diabetes"
          Claire Lugnier (Illkirch)

      "Alterations in 1,2-Diacylglycerols and Ceramides in Diabetic Rat Heart"
          Kenji Okumura (Nagoya)

      "Abnormalities of Intercellular Impulse Propagation in Diabetic Cardiac Muscle"
          Issei Imanaga (Fukuoka)

      WORKSHOP II

      CARDIOVASCULAR DISEASE RISK REDUCTION CLINIC: OPTIMUM MODE
      L

      Chair: Jiri Frohlich

      "Lipid Clinic vs. Cardiovascular Risk Reduction Clinic: Current Pratices
         and Considerations for the Future"
          Jiri Frohlich (Vancouver)

      "Atherosclerosis Reversal Clinic: The Way of the Future"
          Kori Kingsbury (Vancouver)

      "CVD Risk Factor Reduction for High Risk Individuals in a Community Setting"
          John Farquhar (Stanford)     [News Release]

      Sponsored by Merck Frosst

      1000 - 1030 - Coffee/Exhibits

      1030 - 1220 - Concurrent Symposia

    7. CORONARY INTERVENTIONS AND OUTCOMES

      Chairs: Robert Beamish and Allan Downs

      "Clinical Epidemiology of Coronary Artery Disease and Outcomes of Coronary Intervention"
          C. David Naylor (Toronto)

      "Coronary Artery Bypass Surgery in Manitoba (1994 - 1998): Effect of Diabetes on Outcome"
          Andrew Hamilton (Winnipeg)

      "Diabetes and Endothelial Function: Implications for Coronary Anioplasty"
          Todd Anderson (Calgary)

      "The Epidemiology of Peripheral Vascular Surgery and Lower Limb Amputation in Manitoba (1986 -1997)"
          Randy Guzman (Winnipeg)

      Sponsored by Parke Davis

    1. CARDIAC DYSFUNCTION IN DIABETES

    Chairs: John McNeill and Grant Hatch

    "Left Ventricular Diastolic Dysfunction in the Diabetic:
      Role of Collagen Alterations"
        
    J. Timothy Regan (Newark)

    "Effect of Diabetes Mellitus on Hemodynamics and Cardiometabolic
      Correlates in Experimental Myocardial Infarction"
        S. K. Gupta (New Delhi)

    "Cardiac Hypertrophy in Diabetic Patients without Hypertension is
      Associated with Hyperinsulinemia"
        Naoki Makino (Beppu)

    "Cardiac Function in Perfused Hearts from Diabetic and Transgenic Mice"
        D. Severson (Calgary)

    1230 - 1330 - Poster Sessions - Lunch

    1330 - 1530 - PUBLIC FORUM     [News Release]

Coordinator: Barbara Naimark

The public forum will bring together leading scientists with members of the public to discuss key issues on coping with cardiovascular disease at the community level. By means of presentations and open discussion, the participants will have an opportunity to better understand the complex dimensions of cardiovascular disease and its presentation. Those in attendance will be encouraged to ask questions and offer recommendations for further consideration.

Moderator: Diane Swain, Brodacaster, CBC 24 Hours

Speakers:      

Erika Froelicher, Professor of Physiological Nursing, University of California    
"Benefits of Physical Activity"
   
Micheal Stern, Professor of Medicine and Epidemiology, University of Texas
"Diabetes and Cardiovascular Disease in Ethnic Groups

Robert Hegele, Professor of Medicine, University of Western Ontario
"Communities At Risk: Genes or Environment"

Sara Meltzer, Associate Professor of Medicine, McGill University
"Gestational Diabetes and Its Outcome"

Sponsored by Great West Life and London Life

 

CONFERENCE PROGRAM

JUNE 6, 1999

0700-0750 - "Meet the Professor" Session III

Moderator: Vincent Woo

New Guidelines in the Diagnosis of Diabetes Mellitus:
Risks and Benefits.


Discussant: Sara Meltzer

Sponsored by Novartis

0800 - 0950 - Concurrent Symposia

  1. OBESITY, DIABETES AND CARDIOVASCULAR RISK     [News Release]

Chair: J. P. Després

"Reducing the Risk of Cardiovascular Disease in People
  with Type 2 Diabetes"
    Xavier Pi-Sunyer  (New York)     [Abstract]

"Obesity and Insulin Resistance: Insights from
  Adipose Cell Biology"
    David Lau  (Ottawa)     [Abstract]

"Insulin Resistance and Lipoprotein Metabolism"
    Gary Lewis  (Toronto)     [Abstract]

"The Insulin Resistance Syndrome of Abdominal Obesity:
Clinical and Public Health Implications Beyond the
Prevention of Type 2 Diabetes"
    J. P. Després  (Ste. Foy)     [Abstract]     [News Release]

Sponsored by Hoffman la Roche

  1. CARDIAC METABOLISM IN DIABETES

Chairs: Heinrich Taegtmeyer and Jon Slezak

"Transcriptional Modulators for the Diabetic Heart: Differential
  Effects of CPT-1 Inhibition and PDH Activation"
    Heinz Rupp  (Marlburg)

"Transcriptional Responses of the Mechanically Unloaded Heart: A Model for Insulin Resistance?"
    Heinrich Taegtmeyer  (Houston)

"Pathophysiology of Sarcolemmal Phospholipid-mediated Signaling in Diabetic
  Cardiomyopathy"
    Vincenzo Panagia (Winnipeg)

"Abnormal Control of Fatty Acid Oxidation in the Diabetic Rat Heart"
    Gary Lopaschuck (Edmonton)

  1. THE CANADIAN HEART HEALTH INITIATIVE

Chair: Brian O'Connor

"The Canadian Heart Health Initiative"
    Brian O'Connor  (Vancouver)

"G7 Project Promoting Heart Health"
    Jennifer O'Loughlin  (Montreal)

"Heart Health Dessemination: Scientific and Practical Knowledge
  from the Canadian Experience"
    Dexter Harvey (Winnipeg)     [Abstract]

Sponsored by Health Canada

1000 - 1030 - Coffee/Exhibits

1030 - 1220 - Concurrent Symposia

  1. CANADIAN HEART HEALTH STUDY     [News Release]

Chairs: Dale Gelskey and Elinor Wilson

Introduction
    Elinor Wilson  (Ottawa)

"Prevalence of Cardiovascular Risk Factors in Canadian Adults
  with Diabetes Mellitus: The Canadian Heart Health Surveys"
    Michel Joffres  (Halifax)     [Abstract]

"Patterns of Glycosylated Hemoglobin and Fasting Plasma Glucose
  in a Population with Diagnosed and Non-Diagnosed Diabetes"
    Dale Gelskey  (Winnipeg)     [Abstract]

"Relationship of Apo-Lipoproteins A1 and B and Diabetes in the
  Canadian Heart Health Survey"
    Phil Connelly  (Toronto)     [Abstract]

  1. ISCHEMIC HEART DISEASE IN DIABETES

Chair: Grant Pierce

"Ischemic Injury in the Non-Insulin Dependent Diabetic Animal"
    Grant Pierce  (Winnipeg)

"A Pathological Study on the Diabetic Heart Disease of the Rat"
    Shunzo Onishi  (Osaka)

"Response to Ischemic and Endogenous Myocardial Protection
  in the Diabetic Heart"
    Tanya Ravingerova  (Bratislava)

  1. VASCULAR FUNCTION IN DIABETES

Chairs: Keld Kjeldsen and S. S. Agrawal

"Antioxidants as a Option in the Management of Type Two Diabetes and Vascular Disease"
    S. S. Rastogi  (Vikas Marg, Delhi)

"A Possible Role of Oxidative Stress-Induced Activation of Phosphatidylinositol 3-kinase
  (P13-K) and Mitogen-Activated Protein Kinases (MAPK) in Vascular Dysfunction in Diabetes"
    Ashok Srivastava  (Montreal )

"Sympathetic Nervous System in Diabetes and Hypertension"
    C. L. Kaul  (Chandigarh)


"Is Hyperglycemia the Primary Factor Impairing Endothelial
  Function of the Coronary Artery in Diabetes Mellitus?"
   
Maria Koltai  (Budapest)

1230 - 1330 - Poster Sessions - Lunch

1330 - 1520 - Concurrent Symposia

  1. IONIC HOMEOSTASIS IN DIABETES


Chairs: Timothy Regan and James Gilchrist

"Role of Insulin in the Regulation of Endothelial [Ca2+]
  and Vascular Tone"
    Hiroshi Watanabe  (Hamamatsu)

"Human Muscular Na, K-ATPase in Diabetes"
    Keld Kjeldsen  (Copenhagen)

"Human Muscular Na, K-ATPase in Diabetes"
    Keld Kjeldsen (Copenhagen)

"Regulation of Na, K-ATPase in the Diabetic Myocardium:
  Quantitative Changes Related to Modulation of Calcium
  Sensitivity of the Diabetic Heart"
    Attila Ziegelhoffer  (Bratislava)

WORKSHOP III

Tight Clycemic Control

Moderator:   Sora Ludwig

Speakers:    Jean Louis Chiasson
                   Mike Leroux

This workshop will involve a discussion of the merits of glycemic control and the evidence
that outcomes are improved.  It will also review the importance of early detection and
recommended laboratory tests to screen diabetes and monitor the effect of the treatment in the
physician's office.

Sponsored by SmithKline Beecham

1330 - 1520 HEALTH POLICY FORUM

Chair: Greg Hammond

GOVERNMENTS AND COMMUNITY

Speakers:

Sharon Macdonald (Winnipeg)         "Putting Policy into Action"     [Abstract]

Bruce Reeder (Saskatoon)                 "National and International
                                                          Stategies in the Prevention of
                                                          Obesity and Diabetes"     [Abstract]

Wilson Rodger (London, ON)               "The Diabetes Council of
                                                           Canada: Co-ordinating National
                                                           Diabetes Strategies"     [Abstract]

Government Representatives:

W. Phillip Mickelson                         "Federal Role in Health: Canadian
                                                            Diabetes Prevention and Control Strategy"     [Abstract]

Noella Depew  (Winnipeg)                   "Diabetes: The Manitoba Strategy - A Public
                                                            Health Approach"     [Abstract]

Alexa Brewer (Ottawa)                         "Government and Community: The
                                                            Aborginal Diabetes Initiative"     [Abstract]

Sponsored by Health Canada

 

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