Research summary
Dr. Kirk McManus’ research program is focused on addressing three key questions:
- Which genes, proteins, and pathways safeguard our genome and chromosome stability under normal conditions?
- How do disruptions in these molecular systems drive chromosome instability to influence cancer development, progression, and treatment response?
- Can we identify new drug targets that selectively target cancer cells with chromosome instability, while leaving healthy cells unharmed?
His training program offers innovative opportunities for undergraduate, graduate, and post-graduate trainees, preparing them for careers in research, industry, bio-tech, health delivery, education, and policy development.
The McManus research team
The McManus research team studies how cells protect their genetic information, with a special focus on what happens when these protective systems fail. They use advanced genetic, biochemical, and imaging techniques to investigate the genes, proteins, and biological pathways responsible for maintaining genome integrity and chromosome stability.
These safeguards are essential for keeping our DNA accurate and preventing diseases such as cancer. When these systems break down, mistakes can build up in our DNA, which can lead to the development and progression of cancer and also affect how tumors respond to treatments.