Kirk McManus, PhD, MSc

  • Kirk McManus headshot

  • Professor

    Max Rady College of Medicine
    Biochemistry and Medical Genetics
    University of Manitoba
    Paul Albrechtsen Research Institute, CancerCare Manitoba
    Room ON6038 – 675 McDermot Avenue
    Winnipeg, Manitoba R3E 0V9

    Phone: 204-787-2833
    Fax: 204-787-2190
    kirk.mcmanus@umanitoba.ca
    McManus Lab website

Research summary

Dr. Kirk McManus’ research program is focused on addressing three key questions:

  1. Which genes, proteins, and pathways safeguard our genome and chromosome stability under normal conditions? 
  2. How do disruptions in these molecular systems drive chromosome instability to influence cancer development, progression, and treatment response?
  3. Can we identify new drug targets that selectively target cancer cells with chromosome instability, while leaving healthy cells unharmed?

His training program offers innovative opportunities for undergraduate, graduate, and post-graduate trainees, preparing them for careers in research, industry, bio-tech, health delivery, education, and policy development.

The McManus research team

The McManus research team studies how cells protect their genetic information, with a special focus on what happens when these protective systems fail. They use advanced genetic, biochemical, and imaging techniques to investigate the genes, proteins, and biological pathways responsible for maintaining genome integrity and chromosome stability. 

These safeguards are essential for keeping our DNA accurate and preventing diseases such as cancer. When these systems break down, mistakes can build up in our DNA, which can lead to the development and progression of cancer and also affect how tumors respond to treatments.

Research interests

  • Chromosome instability
  • Colorectal cancer
  • Drug target discovery
  • Ovarian cancer
  • Organoid/spheroid models
  • Patient samples
  • Quantitative imaging microscopy
  • siRNA, shRNA, CRISPR/Cas9
  • Synthetic lethality

Research affiliations

  • Senior scientist, Paul Albrechtsen Research Institute, CancerCare Manitoba

Biography

Brief bio

Dr. Kirk McManus is a professor of biochemistry and medical genetics at the Max Rady College of Medicine, University of Manitoba, and a senior scientist within the Paul Albrechtsen Research Institute, CancerCare Manitoba.

Dr. McManus has published extensively in cancer genetics, particularly related to colorectal and ovarian cancers. His team is always looking for motivated students interested in learning more about this important research and joining their efforts to better understand and fight cancer. 

Education

  • Post-doctoral fellowship in molecular oncology, Michael Smith Laboratories, University of British Columbia (2009)
  • PhD in experimental oncology, Cross Cancer Institute, University of Alberta (2004)
  • Master of science in human genetics, University of Manitoba (1999)
  • Bachelor of science (honours) in genetics, University of Manitoba (1995)

Awards

  • Merit Award for Research & Scholarly Work, University of Manitoba (2022)
  • Scientists’ Choice Award, Best Drug Discovery & Development Article of the Year (2017)
  • Merit Award for Research, Teaching & Service, University of Manitoba (2016)
    University of Manitoba Graduate Student Association Teaching Award (2016)

Contact us

Biochemistry and Medical Genetics
Room 336 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada

bmgadmin@umanitoba.ca
204-789-3458