Statistical genomics and bioinformatics

Capabilities include:

• Short-read genome sequencing (Illumina)
• Long-read genome sequencing (Nanopore)
• Short-read and long-read RNA sequencing
• RNA and DNA modification detection via direct long-read sequencing
• NERD-Seq for noncoding RNA sequencing
• Clinical genome sequencing
• Microbial genome sequencing
• Metagenomics sequencing
• ChIP-Seq for profiling chromatin-protein interactions
• RIP-Seq for identifying RNA-protein interactions
• Single-cell transcriptomics to uncover cellular heterogeneity (10x Genomics)
• Customized approaches - tailored solutions for your specific research needs

For customized bioinformatics services, please contact us.

We provide comprehensive computational analysis for genomic, transcriptomic, and epigenomic datasets, including:

• Sequence data quality control and preprocessing
• Read alignment, transcript quantification, and variant calling
• Genome assembly and annotation
• Differential expression and transcriptome analysis
• Gene enrichment and pathway analysis
• ATAC Seq and chromatin accessibility analysis
• Single-cell sequencing analysis
• Methylation and DNA/RNA modification analysis
• Microbiome and metagenomic data analysis
• AI/ML tools for clustering, dimensionality reduction, and classification
• Integrated multi omics and multi-modal workflows (e.g., omics and medical imaging data)
• Data visualization - from standard charts to custom, complex visuals
• Customized and automated pipelines

Data types supported:

• Genomics: long read and short read genomes, clinical genomes
• Transcriptomics: RNA-Seq, long read RNA, noncoding RNA profiling
• Epigenomics: methylation, chromatin accessibility (ATAC Seq)
• Epitranscriptomics: RNA modifications, direct RNA sequencing
• Protein-RNA interactions: RIP Seq and related assays

For customized bioinformatics services, please contact us.

We offer statistical and analytical expertise to support robust study design and interpretation.

Study design and experimental planning

We support the development of robust study frameworks tailored to your research goals. Services include:

• Study design consultation for genomic, transcriptomic, and clinical research
• Family-based and population-based case-control study design
• Analysis of discrete or quantitative traits
• Exploring haplotype associations in related and unrelated individuals
• Power analysis and sample size determination
• Guidance on metadata collection and experimental variables

Quality control and data integrity

Ensuring high quality, reliable genomic data is foundational for downstream analysis. Our QC services include:

• Missingness and minor allele frequency analysis
• Hardy-Weinberg equilibrium testing
• Evaluation of population stratification and potential biases

Genetic linkage and mapping studies

We provide linkage based methods to identify regions of interest and characterize inheritance patterns. Support includes:

• Homozygosity mapping to identify shared genetic regions
• Assessment of covariate effects on linkage signals

Association analyses

We perform a broad spectrum of association studies to identify genetic, transcriptomic, and epigenomic contributors to traits and disease. Analytical capabilities:

• Genome wide and transcriptome-wide association studies (GWAS, TWAS)
• Epigenome-wide association studies (EWAS) and methylation quantitative trait locus (mQTL) mapping
• Expression and splicing quantitative trait locus mapping (eQTL, sQTL)
• Rare variant analysis using genome and exome sequencing data
• Copy number and structural variation analysis
• Population genetics and ancestry inference

Causal variant and locus investigation

We support downstream interpretation of association signals by integrating statistical, functional, and clinical evidence to prioritize variants and loci for follow up. Available services include:

• Fine mapping to identify likely causal variants within association regions
• Variant annotation and interpretation using population, functional, and regulatory resources
• Prioritization of variants, genes, and loci based on statistical signals, functional context, and biological plausibility
• Clinical and translational genomics support:
  • Incorporation of phenotype and clinical metadata to refine significance
  • Harmonization with knowledge bases
  • Identification of findings with potential translational relevance for follow-up
  • Clear summaries distinguishing known, predicted, and uncertain effects
• Mendelian randomization studies to assess causal relationships

Genetic risk prediction

We support quantitative risk modeling using genetic information. We offer:

• Polygenic risk score (PRS) analysis and its potential clinical applications

Results interpretation and manuscript support

We ensure your findings are clearly communicated and publication-ready.

• Reproducible and manuscript-ready analysis workflows
• Publication-quality figures, visualizations and tables
• Concise summaries of methods and results for manuscripts and reports

For more information or to discuss how we can support your research, please contact us.

We provide one on one consultations to assist with study design, data preparation, workflow planning, and interpretation of analysis results. Our team works with researchers at all levels of experience, from graduate students to senior investigators.

We offer practical, hands on training sessions and technical workshops covering topics such as sequencing workflows, bioinformatics pipelines, data management, and multi omics analysis. These sessions are designed to help participants develop the skills needed to work confidently with their own datasets.

To access a full list of upcoming national training opportunities, please visit the Canadian Bioinformatics workshops schedule.

We are proud to serve a regional node for the Canadian Bioinformatics Hub (CBH), supporting bioinformatics and computational biology capacity across Manitoba and Saskatchewan. Learn more about the CBH Prairies Node.

As our training initiatives expand, we will continue to add new learning materials, tutorials, and workshop resources to this section to support our growing research community.