Kevin Pan

Research in our lab focuses on the chemosensation of fish, with particular emphasis on olfaction (smell) and gustation (taste). The two main topics in the lab are:

1. Investigate the molecular, cellular, and neural mechanisms underlying fish chemosensation and how they shape behaviours such as foraging, predator avoidance, reproduction, and migration.
2. The mechanisms underlying chemosensation impairment due to stressful environments such as hypoxia (low O2), ocean acidification (high CO2 and low pH), and extreme temperatures.

To address these questions, the lab utilizes zebrafish as a model for its ease of genetic manipulation. Using cutting-edge molecular, genetic, and fluorescence imaging techniques, including CRISPR/Cas9 genome editing, Tol2-mediated transgenesis, and in vivo calcium imaging, we are able to manipulate genes involved in chemosensation pathways and visualize neural activity in real time. Further integration of these approaches with behavioural and physiological assays allows us to uncover how sensory circuits detect and process environmental chemical cues, and how they are impaired by stressful environmental conditions.

This research provides fundamental insights into the biology of sensory systems while advancing our understanding of how environmental change influences aquatic organisms. If this research piques your interest, contact kevin.pan@umanitoba.ca for opportunities in the lab. We are constantly seeking highly motivated students and postdocs.

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